Peptide serum markers in islet autoantibody-positive children

Von Toerne C, Laimighofer M, Achenbach P, Beyerlein A, Gala TDLH, Krumsiek J, Theis FJ, Ziegler AG, Hauck SM (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Diabetologia Springer Verlag (Germany)

Book Volume: 60

Pages Range: 287-295

Journal Issue: 2

DOI: 10.1007/s00125-016-4150-x

Abstract

Aims/hypothesis: We sought to identify minimal sets of serum peptide signatures as markers for islet autoimmunity and predictors of progression rates to clinical type 1 diabetes in a case–control study. Methods: A double cross-validation approach was applied to first prioritise peptides from a shotgun proteomic approach in 45 islet autoantibody-positive and -negative children from the BABYDIAB/BABYDIET birth cohorts. Targeted proteomics for 82 discriminating peptides were then applied to samples from another 140 children from these cohorts. Results: A total of 41 peptides (26 proteins) enriched for the functional category lipid metabolism were significantly different between islet autoantibody-positive and autoantibody-negative children. Two peptides (from apolipoprotein M and apolipoprotein C-IV) were sufficient to discriminate autoantibody-positive from autoantibody-negative children. Hepatocyte growth factor activator, complement factor H, ceruloplasmin and age predicted progression time to type 1 diabetes with a significant improvement compared with age alone. Conclusion/interpretation: Distinct peptide signatures indicate islet autoimmunity prior to the clinical manifestation of type 1 diabetes and enable refined staging of the presymptomatic disease period.

Involved external institutions

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE) Deutsches Zentrum für Diabetesforschung e.V. (DZD) DE Germany (DE)

How to cite

APA:

Von Toerne, C., Laimighofer, M., Achenbach, P., Beyerlein, A., Gala, T.D.L.H., Krumsiek, J.,... Hauck, S.M. (2017). Peptide serum markers in islet autoantibody-positive children. Diabetologia, 60(2), 287-295. https://doi.org/10.1007/s00125-016-4150-x

MLA:

Von Toerne, Christine, et al. "Peptide serum markers in islet autoantibody-positive children." Diabetologia 60.2 (2017): 287-295.

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