Flow-mediated dilatation test using optoacoustic imaging: A proof-of-concept
Karlas A, Reber J, Diot G, Bozhko D, Anastasopoulou M, Ibrahim T, Schwaiger M, Hyafil F, Ntziachristos V (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 8
Pages Range: 3395-3403
Journal Issue: 7
DOI: 10.1364/BOE.8.003395
Abstract
Label-free multispectral optoacoustic tomography (MSOT) has recently shown superior performance in visualizing the morphology of human vasculature, especially of smaller vessels, compared to ultrasonography. Herein, we extend these observations towards MSOT interrogation of macrovascular endothelial function. We employed a real-time handheld MSOT scanner to assess flow-mediated dilatation (FMD), a technique used to characterize endothelial function. A data processing scheme was developed to quantify the dimensions and diameter changes of arteries in humans and determine wall distensibility parameters. By enabling high-resolution delineation of the blood-vessel wall in a cross-sectional fashion, the findings suggest MSOT as a capable alternative to ultrasonography for clinical FMD measurements.
Involved external institutions
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
Technische Universität München (TUM)
Germany (DE)
Klinikum rechts der Isar
Germany (DE)
Germany (DE)
Technische Universität München (TUM)
Germany (DE)
Klinikum rechts der Isar
Germany (DE)
How to cite
APA:
Karlas, A., Reber, J., Diot, G., Bozhko, D., Anastasopoulou, M., Ibrahim, T.,... Ntziachristos, V. (2017). Flow-mediated dilatation test using optoacoustic imaging: A proof-of-concept. Biomedical Optics Express, 8(7), 3395-3403. https://doi.org/10.1364/BOE.8.003395
MLA:
Karlas, Angelos, et al. "Flow-mediated dilatation test using optoacoustic imaging: A proof-of-concept." Biomedical Optics Express 8.7 (2017): 3395-3403.
BibTeX: Download