In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source

Gradl R, Dierolf M, Guenther B, Hehn L, Moeller W, Kutschke D, Yang L, Donnelley M, Murrie R, Erl A, Stoeger T, Gleich B, Achterhold K, Schmid O, Pfeiffer F, Morgan KS (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 8

Article Number: 6788

Journal Issue: 1

DOI: 10.1038/s41598-018-24763-8

Abstract

We describe the first dynamic and the first in vivo X-ray imaging studies successfully performed at a laser-undulator-based compact synchrotron light source. The X-ray properties of this source enable time-sequence propagation-based X-ray phase-contrast imaging. We focus here on non-invasive imaging for respiratory treatment development and physiological understanding. In small animals, we capture the regional delivery of respiratory treatment, and two measures of respiratory health that can reveal the effectiveness of a treatment; lung motion and mucociliary clearance. The results demonstrate the ability of this set-up to perform laboratory-based dynamic imaging, specifically in small animal models, and with the possibility of longitudinal studies.

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) Deutsches Zentrum für Lungenforschung e.V. (DZL) DE Germany (DE) University of Adelaide AU Australia (AU) Monash University AU Australia (AU)

How to cite

APA:

Gradl, R., Dierolf, M., Guenther, B., Hehn, L., Moeller, W., Kutschke, D.,... Morgan, K.S. (2018). In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-24763-8

MLA:

Gradl, Regine, et al. "In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source." Scientific Reports 8.1 (2018).

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