Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation
Li Y, Schnabl K, Gabler SM, Willershaeuser M, Reber J, Karlas A, Laurila S, Lahesmaa M, Din MU, Bast-Habersbrunner A, Virtanen KA, Fromme T, Bolze F, O'Farrell LS, Alsina-Fernandez J, Coskun T, Ntziachristos V, Nuutila P, Klingenspor M (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 175
Pages Range: 1561-1574.e12
Journal Issue: 6
DOI: 10.1016/j.cell.2018.10.016
Abstract
The molecular mediator and functional significance of meal-associated brown fat (BAT) thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non-sympathetic BAT activator mediating prandial thermogenesis, which consequentially induces satiation, thereby establishing a gut-secretin-BAT-brain axis in mammals with a physiological role of prandial thermogenesis in the control of satiation. Mechanistically, meal-associated rise in circulating secretin activates BAT thermogenesis by stimulating lipolysis upon binding to secretin receptors in brown adipocytes, which is sensed in the brain and promotes satiation. Chronic infusion of a modified human secretin transiently elevates energy expenditure in diet-induced obese mice. Clinical trials with human subjects showed that thermogenesis after a single-meal ingestion correlated with postprandial secretin levels and that secretin infusions increased glucose uptake in BAT. Collectively, our findings highlight the largely unappreciated function of BAT in the control of satiation and qualify BAT as an even more attractive target for treating obesity.
Involved external institutions
Technische Universität München (TUM)
Germany (DE)
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
University of Turku / Turun yliopisto
Finland (FI)
Eli Lilly and Company
United States (USA) (US)
Germany (DE)
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
University of Turku / Turun yliopisto
Finland (FI)
Eli Lilly and Company
United States (USA) (US)
How to cite
APA:
Li, Y., Schnabl, K., Gabler, S.-M., Willershaeuser, M., Reber, J., Karlas, A.,... Klingenspor, M. (2018). Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation. Cell, 175(6), 1561-1574.e12. https://doi.org/10.1016/j.cell.2018.10.016
MLA:
Li, Yongguo, et al. "Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation." Cell 175.6 (2018): 1561-1574.e12.
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