Effects of Endurance Training on Detrimental Structural, Cellular, and Functional Alterations in Skeletal Muscles of Heart Failure With Preserved Ejection Fraction
Bowen TS, Herz C, Rolim NPL, Berre AMO, Halle M, Kricke A, Linke A, Da Silva GJ, Wisloff U, Adams V (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 24
Pages Range: 603-613
Journal Issue: 9
DOI: 10.1016/j.cardfail.2018.08.009
Abstract
Background: Heart failure with preserved ejection fraction (HFpEF) is underpinned by detrimental skeletal muscle alterations that contribute to disease severity, yet underlying mechanisms and therapeutic treatments remain poorly established. This study used a nonhuman animal model of HFpEF to better understand whether skeletal muscle abnormalities were (1) fiber-type specific and (2) reversible by various exercise training regimes. Methods and Results: Lean control rats were compared with obese ZSF1 rats at 20 weeks and then 8 weeks after sedentary, high-intensity interval training, or moderate continuous treadmill exercise. Oxidative soleus and glycolytic extensor digitorum longus (EDL) muscles were assessed for fiber size, capillarity, glycolytic metabolism, autophagy, and contractile function. HFpEF reduced fiber size and capillarity by 20%–50% (P <.05) in both soleus and EDL, but these effects were not reversed by endurance training. In contrast, both endurance training regimes in HFpEF attenuated the elevated lactate dehydrogenase activity observed in the soleus. Autophagy was down-regulated in EDL and up-regulated in soleus (P <.05), with no influence of endurance training. HFpEF impaired contractile forces of both muscles by ∼20% (P <.05), and these were not reversed by training. Conclusions: Obesity-related HFpEF was associated with detrimental structural, cellular, and functional alterations to both slow-oxidative and fast-glycolytic skeletal muscles that could not be reversed by endurance training.
Involved external institutions
University of Leeds
United Kingdom (GB)
Universität Leipzig
Germany (DE)
NTNU Trondheim - Norwegian University of Science and Technology
Norway (NO)
Technische Universität München (TUM)
Germany (DE)
Technische Universität Dresden
Germany (DE)
United Kingdom (GB)
Universität Leipzig
Germany (DE)
NTNU Trondheim - Norwegian University of Science and Technology
Norway (NO)
Technische Universität München (TUM)
Germany (DE)
Technische Universität Dresden
Germany (DE)
How to cite
APA:
Bowen, T.S., Herz, C., Rolim, N.P.L., Berre, A.-M.O., Halle, M., Kricke, A.,... Adams, V. (2018). Effects of Endurance Training on Detrimental Structural, Cellular, and Functional Alterations in Skeletal Muscles of Heart Failure With Preserved Ejection Fraction. Journal of Cardiac Failure, 24(9), 603-613. https://doi.org/10.1016/j.cardfail.2018.08.009
MLA:
Bowen, T. Scott, et al. "Effects of Endurance Training on Detrimental Structural, Cellular, and Functional Alterations in Skeletal Muscles of Heart Failure With Preserved Ejection Fraction." Journal of Cardiac Failure 24.9 (2018): 603-613.
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