Adeberg S, Harrabi SB, Bougatf N, Verma V, Windisch P, Bernhardt D, Combs SE, Herfarth K, Debus J, Rieken S (2018)
Publication Type: Journal article
Publication year: 2018
Book Volume: 10
Article Number: 401
Journal Issue: 11
(1) Background: Selecting patients that will benefit the most from proton radiotherapy (PRT) is of major importance. This study sought to assess dose reductions to numerous organs-at-risk (OARs) with PRT, as compared to three-dimensional conformal radiotherapy (3DCRT) and volumetric-modulated arc therapy (VMAT), as a function of tumor location. (2) Materials/Methods: Patients with intracranial neoplasms (all treated with PRT) were stratified into five location-based groups (frontal, suprasellar, temporal, parietal, posterior cranial fossa; n = 10 per group). Each patient was re-planned for 3DCRT and intensity-modulated radiotherapy (IMRT) using similar methodology, including the originally planned target and organ-at-risk (OAR) dose constraints. (3) Results: In parietal tumors, PRT showed the most pronounced dose reductions. PRT lowered doses to nearly every OAR, most notably the optical system and several contralateral structures (subventricular zone, thalamus, hippocampus). For frontal lobe cases, the greatest relative dose reductions in mean dose (D
APA:
Adeberg, S., Harrabi, S.B., Bougatf, N., Verma, V., Windisch, P., Bernhardt, D.,... Rieken, S. (2018). Dosimetric comparison of proton radiation therapy, volumetric modulated arc therapy, and three-dimensional conformal radiotherapy based on intracranial tumor location. Cancers, 10(11). https://doi.org/10.3390/cancers10110401
MLA:
Adeberg, Sebastian, et al. "Dosimetric comparison of proton radiation therapy, volumetric modulated arc therapy, and three-dimensional conformal radiotherapy based on intracranial tumor location." Cancers 10.11 (2018).
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