The human lung cell atlas: A high-resolution reference map of the human lung in health and disease

Schiller HB, Montoro DT, Simon LM, Rawlins EL, Meyer KB, Strunz M, Braga FAV, Timens W, Koppelman GH, Budinger GRS, Burgess JK, Waghray A, Van Den Berge M, Theis FJ, Regev A, Kaminski N, Rajagopal J, Teichmann SA, Misharin A, Nawijn MC (2019)

Publication Type: Journal article, Review article

Publication year: 2019

Journal

American journal of respiratory cell and molecular biology

Book Volume: 61

Pages Range: 31-41

Journal Issue: 1

DOI: 10.1165/rcmb.2018-0416TR

Abstract

Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing the identification of disease mechanisms and will aid the design of novel diagnostic and personalized therapeutic regimens. Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to study individual cells within a tissue, classify these into cell types, and characterize variations in their molecular profiles as a function of genetics, environment, cell-cell interactions, developmental processes, aging, or disease. Integration of these cell state definitions with spatial information allows the in-depth molecular description of cellular neighborhoods and tissue microenvironments, including the tissue resident structural and immune cells, the tissue matrix, and the microbiome. The Human Cell Atlas consortium aims to characterize all cells in the healthy human body and has prioritized lung tissue as one of the flagship projects. Here, we present the rationale, the approach, and the expected impact of a Human Lung Cell Atlas.

Involved external institutions

Harvard University US United States (USA) (US) Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich DE Germany (DE) University of Cambridge GB United Kingdom (GB) Wellcome Trust Sanger Institute - Genome Research Limited GB United Kingdom (GB) University of Groningen / Rijksuniversiteit Groningen NL Netherlands (NL) Northwestern University US United States (USA) (US) Eli and Edythe L. Broad Institute of MIT and Harvard US United States (USA) (US) Yale University US United States (USA) (US)

How to cite

APA:

Schiller, H.B., Montoro, D.T., Simon, L.M., Rawlins, E.L., Meyer, K.B., Strunz, M.,... Nawijn, M.C. (2019). The human lung cell atlas: A high-resolution reference map of the human lung in health and disease. American journal of respiratory cell and molecular biology, 61(1), 31-41. https://doi.org/10.1165/rcmb.2018-0416TR

MLA:

Schiller, Herbert B., et al. "The human lung cell atlas: A high-resolution reference map of the human lung in health and disease." American journal of respiratory cell and molecular biology 61.1 (2019): 31-41.

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