Perfusion-ventilation CT via three-material differentiation in dual-layer CT: a feasibility study
Sauter AP, Hammel J, Ehn S, Achterhold K, Kopp FK, Kimm MA, Mei K, Laugerette A, Pfeiffer F, Rummeny EJ, Pfeiffer D, Noel PB (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 9
Article Number: 5837
Journal Issue: 1
DOI: 10.1038/s41598-019-42330-7
Abstract
Dual-Energy Computed Tomography is of significant clinical interest due to the possibility of material differentiation and quantification. In current clinical routine, primarily two materials are differentiated, e.g., iodine and soft-tissue. A ventilation-perfusion-examination acquired within a single CT scan requires two contrast agents, e.g., xenon and gadolinium, and a three-material differentiation. In the current study, we have developed a solution for three-material differentiation for a ventilation-perfusion-examination. A landrace pig was examined using a dual-layer CT, and three scans were performed: (1) native; (2) xenon ventilation only; (3) xenon ventilation and gadolinium perfusion. An in-house developed algorithm was used to obtain xenon- and gadolinium-density maps. Firstly, lung tissue was segmented from other tissue. Consequently, a two-material decomposition was performed for lung tissue (xenon/soft-tissue) and for remaining tissue (gadolinium/soft-tissue). Results reveal that it was possible to differentiate xenon and gadolinium in a ventilation/perfusion scan of a pig, resulting in xenon and gadolinium density maps. By summation of both density maps, a three-material differentiation (xenon/gadolinium/soft tissue) can be performed and thus, xenon ventilation and gadolinium perfusion can be visualized in a single CT scan. In an additionally performed phantom study, xenon and gadolinium quantification showed very accurate results (r > 0.999 between measured and known concentrations).
Involved external institutions
Germany (DE)How to cite
APA:
Sauter, A.P., Hammel, J., Ehn, S., Achterhold, K., Kopp, F.K., Kimm, M.A.,... Noel, P.B. (2019). Perfusion-ventilation CT via three-material differentiation in dual-layer CT: a feasibility study. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-42330-7
MLA:
Sauter, Andreas P., et al. "Perfusion-ventilation CT via three-material differentiation in dual-layer CT: a feasibility study." Scientific Reports 9.1 (2019).
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