Complementarity of molecular and elemental mass spectrometric imaging of Gadovist™in mouse tissues

Trog S, El-Khatib AH, Beck S, Makowski MR, Jakubowski N, Linscheid MW (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Analytical and Bioanalytical Chemistry Springer

Book Volume: 411

Pages Range: 629-637

Journal Issue: 3

DOI: 10.1007/s00216-018-1477-9

Abstract

Drug biodistribution analyses can be considered a key issue in pharmaceutical discovery and development. Here, mass spectrometric imaging can be employed as a powerful tool to investigate distributions of drug compounds in biologically and medically relevant tissue sections. Both matrix-assisted laser desorption ionization–mass spectrometric imaging as molecular method and laser ablation inductively coupled plasma–mass spectrometric imaging as elemental detection method were applied to determine drug distributions in tissue thin sections. Several mouse organs including the heart, kidney, liver, and brain were analyzed with regard to distribution of Gadovist ™ , a gadolinium-based contrast agent already approved for clinical investigation. This work demonstrated the successful detection and localization of Gadovist ™ in several organs. Furthermore, the results gave evidence that gadolinium-based contrast agents in general can be well analyzed by mass spectrometric imaging methods. In conclusion, the combined application of molecular and elemental mass spectrometry could complement each other and thus confirm analytical results or provide additional information.

Involved external institutions

Humboldt-Universität zu Berlin DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE) Bundesanstalt für Materialforschung und -prüfung (BAM) DE Germany (DE)

How to cite

APA:

Trog, S., El-Khatib, A.H., Beck, S., Makowski, M.R., Jakubowski, N., & Linscheid, M.W. (2019). Complementarity of molecular and elemental mass spectrometric imaging of Gadovist™in mouse tissues. Analytical and Bioanalytical Chemistry, 411(3), 629-637. https://doi.org/10.1007/s00216-018-1477-9

MLA:

Trog, Sabrina, et al. "Complementarity of molecular and elemental mass spectrometric imaging of Gadovist™in mouse tissues." Analytical and Bioanalytical Chemistry 411.3 (2019): 629-637.

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