Sex and long-term outcomes after implantation of the Absorb bioresorbable vascular scaffold for treatment of coronary artery disease
Baquet M, Hoppmann P, Grundmann D, Schmidt W, Kufner S, Theiss HD, Brunner S, Wiebe J, Eickhoff M, Jochheim D, Byrne RA, Laugwitz KL, Schunkert H, Massberg S, Kastrati A, Mehilli J (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 15
Pages Range: 615-622
Journal Issue: 7
Abstract
Aims: Women and men suffering from coronary artery disease differ in their risk profiles. We sought to investigate the impact of sex on two-year outcomes after BVS implantation in routine clinical practice. Methods and results: Sex-based analysis of clinical outcomes was carried out by pooling the individual patient data of the ISAR-ABSORB and KUM-ABSORB registries performed in four high-volume tertiary centres in Munich. Of the total of 1,032 patients, 259 (25.1%) were women. The primary composite endpoint of death, target vessel myocardial infarction (TV-MI) and target lesion revascularisation (TLR) up to two years occurred in 13.2% of women and 17.9% of men (p=0.12). Compared to men, women experienced numerically lower rates of TLR and definite or probable BVS thrombosis - 7.5% vs 12.4% (p=0.051) and 1.2% and 2.7% (p=0.20), respectively. Independent predictors of increased risk for TLR were use of smaller size BVS (HR 1.28, 95% CI: 1.02-1.62), while being a woman was a protective factor (HR 0.59, 95% CI: 0.35-1.00). Conclusions: BVS used in a routine setting tend to perform better among women compared to men, which might be partially related to the lower complexity of their coronary artery disease.
Involved external institutions
Germany (DE)How to cite
APA:
Baquet, M., Hoppmann, P., Grundmann, D., Schmidt, W., Kufner, S., Theiss, H.D.,... Mehilli, J. (2019). Sex and long-term outcomes after implantation of the Absorb bioresorbable vascular scaffold for treatment of coronary artery disease. EuroIntervention, 15(7), 615-622. https://doi.org/10.4244/EIJ-D-18-00603
MLA:
Baquet, Moritz, et al. "Sex and long-term outcomes after implantation of the Absorb bioresorbable vascular scaffold for treatment of coronary artery disease." EuroIntervention 15.7 (2019): 615-622.
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