Small animal IGRT special feature: REVIEW ARTICLE Spatially fractionated proton minibeams
Meyer J, Eley J, Schmid TE, Combs SE, Dendale R, Prezado Y (2019)
Publication Type: Journal article, Review article
Publication year: 2019
Journal
Book Volume: 92
Article Number: 20180466.
Journal Issue: 1095
DOI: 10.1259/bjr.20180466
Abstract
Extraordinary normal tissue response to highly spatially fractionated X-ray beams has been explored for over 25 years. More recently, alternative radiation sources have been developed and utilized with the aim to evoke comparable effects. These include protons, which lend themselves well for this endeavour due to their physical depth dose characteristics as well as corresponding variable biological effectiveness. This paper addresses the motivation for using protons to generate spatially fractionated beams and reviews the technological implementations and experimental results to date. This includes simulation and feasibility studies, collimation and beam characteristics, dosimetry and biological considerations as well as the results of in vivo and in vitro studies. Experimental results are emerging indicating an extraordinary normal tissue sparing effect analogous to what has been observed for synchrotron generated X-ray microbeams. The potential for translational research and feasibility of spatially modulated proton beams in clinical settings is discussed.
Involved external institutions
Technische Universität München (TUM)
Germany (DE)
University of Washington
United States (USA) (US)
University of Maryland
United States (USA) (US)
Proton Therapy Center / Centre de protonthérapie d'Orsay
France (FR)
University of Paris 11 - Paris-Sud / Université Paris XI Paris-Sud
France (FR)
Germany (DE)
University of Washington
United States (USA) (US)
University of Maryland
United States (USA) (US)
Proton Therapy Center / Centre de protonthérapie d'Orsay
France (FR)
University of Paris 11 - Paris-Sud / Université Paris XI Paris-Sud
France (FR)
How to cite
APA:
Meyer, J., Eley, J., Schmid, T.E., Combs, S.E., Dendale, R., & Prezado, Y. (2019). Small animal IGRT special feature: REVIEW ARTICLE Spatially fractionated proton minibeams. British Journal of Radiology, 92(1095). https://doi.org/10.1259/bjr.20180466
MLA:
Meyer, Juergen, et al. "Small animal IGRT special feature: REVIEW ARTICLE Spatially fractionated proton minibeams." British Journal of Radiology 92.1095 (2019).
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