PET imaging in patients with brain metastasis—report of the RANO/PET group

Galldiks N, Langen KJ, Albert NL, Chamberlain M, Soffietti R, Kim MM, Law I, Le Rhun E, Chang S, Schwarting J, Combs SE, Preusser M, Forsyth P, Pope W, Weller M, Tonn JC (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Book Volume: 21

Pages Range: 584-595

Journal Issue: 5

DOI: 10.1093/neuonc/noz003

Abstract

Brain metastases (BM) from extracranial cancer are associated with significant morbidity and mortality. Effective local treatment options are stereotactic radiotherapy, including radiosurgery or fractionated external beam radiotherapy, and surgical resection.The use of systemic treatment for intracranial disease control also is improving. BM diagnosis, treatment planning, and follow-up is most often based on contrast-enhanced magnetic resonance imaging (MRI). However, anatomic imaging modalities including standard MRI have limitations in accurately characterizing posttherapeutic reactive changes and treatment response. Molecular imaging techniques such as positron emission tomography (PET) characterize specific metabolic and cellular features of metastases, potentially providing clinically relevant information supplementing anatomic MRI. Here, the Response Assessment in Neuro-Oncology working group provides recommendations for the use of PET imaging in the clinical management of patients with BM based on evidence from studies validated by histology and/or clinical outcome.

Involved external institutions

Universitätsklinikum Köln Germany (DE) Forschungszentrum Jülich / Research Centre Jülich (FZJ) Germany (DE) Ludwig-Maximilians-Universität (LMU) Germany (DE) University of Washington United States (USA) (US) University of Turin / Università degli Studi di Torino (UNITO) Italy (IT) University of Michigan United States (USA) (US) University of Copenhagen Denmark (DK) Centre Hospitalier Régional Universitaire de Lille (CHRU de Lille) France (FR) University of California San Francisco (UCSF) United States (USA) (US) Technische Universität München (TUM) Germany (DE) Medizinische Universität Wien Austria (AT) University of South Florida (USF) United States (USA) (US) University of California Los Angeles (UCLA) United States (USA) (US) Universitätsspital Zürich (USZ) Switzerland (CH)

How to cite

APA:

Galldiks, N., Langen, K.-J., Albert, N.L., Chamberlain, M., Soffietti, R., Kim, M.M.,... Tonn, J.C. (2019). PET imaging in patients with brain metastasis—report of the RANO/PET group. Neuro-Oncology, 21(5), 584-595. https://doi.org/10.1093/neuonc/noz003

MLA:

Galldiks, Norbert, et al. "PET imaging in patients with brain metastasis—report of the RANO/PET group." Neuro-Oncology 21.5 (2019): 584-595.

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