Beam size limit for pencil minibeam radiotherapy determined from side effects in an in-vivo mouse ear model
Sammer M, Teiluf K, Girst S, Greubel C, Reindl J, Ilicic K, Walsh DWM, Aichler M, Walch A, Combs SE, Wilkens JJ, Dollinger G, Schmid TE (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 14
Article Number: e0221454
Journal Issue: 9
DOI: 10.1371/journal.pone.0221454
Abstract
Side effects caused by radiation are a limiting factor to the amount of dose that can be applied to a tumor volume. A novel method to reduce side effects in radiotherapy is the use of spatial fractionation, in which a pattern of sub-millimeter beams (minibeams) is applied to spare healthy tissue. In order to determine the skin reactions in dependence of single beam sizes, which are relevant for spatially fractionated radiotherapy approaches, single pencil beams of submillimeter to 6 millimeter size were applied in BALB/c mice ears at a Small Animal Radiation Research Platform (SARRP) with a plateau dose of 60 Gy. Radiation toxicities in the ears were observed for 25 days after irradiation. Severe radiation responses were found for beams ≥ 3 mm diameter. The larger the beam diameter the stronger the observed reactions. No ear swelling and barely reddening or desquamation were found for the smallest beam sizes (0.5 and 1 mm). The findings were confirmed by histological sections. Sub-millimeter beams are preferred in minibeam therapy to obtain optimized tissue sparing. The gradual increase of radiation toxicity with beam size shows that also larger beams are capable of healthy tissue sparing in spatial fractionation.
Involved external institutions
Universität der Bundeswehr München
Germany (DE)
Technische Universität München (TUM)
Germany (DE)
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
Germany (DE)
Technische Universität München (TUM)
Germany (DE)
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich
Germany (DE)
How to cite
APA:
Sammer, M., Teiluf, K., Girst, S., Greubel, C., Reindl, J., Ilicic, K.,... Schmid, T.E. (2019). Beam size limit for pencil minibeam radiotherapy determined from side effects in an in-vivo mouse ear model. PLoS ONE, 14(9). https://doi.org/10.1371/journal.pone.0221454
MLA:
Sammer, Matthias, et al. "Beam size limit for pencil minibeam radiotherapy determined from side effects in an in-vivo mouse ear model." PLoS ONE 14.9 (2019).
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