Dynamic K-edge Subtraction Fluoroscopy at a Compact Inverse-Compton Synchrotron X-ray Source

Kulpe S, Dierolf M, Guenther B, Brantl J, Busse M, Achterhold K, Gleich B, Pfeiffer F, Pfeiffer D (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 10

Article Number: 9612

Journal Issue: 1

DOI: 10.1038/s41598-020-66414-x

Abstract

X-ray fluoroscopy is a commonly applied diagnostic tool for morphological and functional evaluation of the intestine in clinical routine. Acquisition of repetitive X-ray images following oral or rectal application of iodine contrast agent visualizes the time dependent distribution of the contrast medium, and helps to detect for example leakages, tumors or functional disorders. However, movements of the intestine and air trapped inside usually prevent temporal subtraction imaging to be applied to fluoroscopy of the gastrointestinal tract. K-edge subtraction (KES) imaging would enable subtraction fluoroscopy because it allows for imaging of moving organs with little artefacts. Although KES imaging is a well established technique at synchrotron sources, this imaging method is not applied in clinical routine as it relies on brilliant synchrotron radiation. Recently emerging compact synchrotron X-ray sources could provide a quasi-monochromatic, high-flux X-ray beam and allow for the application of KES in a laboratory environment. Here, we present a filter-based dynamic KES approach at the Munich Compact Light Source (MuCLS), the first user-dedicated installation of a compact synchrotron X-ray source worldwide. Compared to conventional temporal subtraction X-ray radiography, our approach increases the contrast while reducing the generated image artefacts.

Involved external institutions

Technische Universität München (TUM) DE Germany (DE) Klinikum rechts der Isar DE Germany (DE)

How to cite

APA:

Kulpe, S., Dierolf, M., Guenther, B., Brantl, J., Busse, M., Achterhold, K.,... Pfeiffer, D. (2020). Dynamic K-edge Subtraction Fluoroscopy at a Compact Inverse-Compton Synchrotron X-ray Source. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-66414-x

MLA:

Kulpe, Stephanie, et al. "Dynamic K-edge Subtraction Fluoroscopy at a Compact Inverse-Compton Synchrotron X-ray Source." Scientific Reports 10.1 (2020).

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