Low-cost single-point optoacoustic sensor for spectroscopic measurement of local vascular oxygenation
Stylogiannis A, Riobo L, Prade L, Glasl S, Klein S, Lucidi G, Fuchs M, Saur D, Ntziachristos V (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 45
Journal Issue: 24
DOI: 10.1364/OL.412034
Abstract
Optical sensors developed for the assessment of oxygen in tissue microvasculature, such as those based on near-infrared spectroscopy, are limited in application by light scattering. Optoacoustic methods are insensitive to light scattering, and therefore, they can provide higher specificity and accuracy when quantifying local vascular oxygenation. However, currently, to the best of our knowledge, there is no low-cost, single point, optoacoustic sensor for the dedicated measurement of oxygen saturation in tissue microvasculature. This work introduces a spectroscopic optoacoustic sensor (SPOAS) for the non-invasive measurement of local vascular oxygenation in real time. SPOAS employs continuous wave laser diodes and measures at a single point, which makes it low-cost and portable. The SPOAS performance was benchmarked using blood phantoms, and it showed excellent linear correlation (R2 = 0.98) with a blood gas analyzer. Subsequent measurements of local vascular oxygenation in living mice during an oxygen stress test correlated well with simultaneous readings from a reference instrument.
Involved external institutions
Germany (DE)How to cite
APA:
Stylogiannis, A., Riobo, L., Prade, L., Glasl, S., Klein, S., Lucidi, G.,... Ntziachristos, V. (2020). Low-cost single-point optoacoustic sensor for spectroscopic measurement of local vascular oxygenation. Optics Letters, 45(24). https://doi.org/10.1364/OL.412034
MLA:
Stylogiannis, Antonios, et al. "Low-cost single-point optoacoustic sensor for spectroscopic measurement of local vascular oxygenation." Optics Letters 45.24 (2020).
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