Estimating vertebral bone marrow fat unsaturation based on short-TE STEAM MRS
Syvaeri J, Ruschke S, Dieckmeyer M, Hauner HH, Junker D, Makowski MR, Baum T, Karampinos DC (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 85
Pages Range: 615-626
Journal Issue: 2
DOI: 10.1002/mrm.28453
Abstract
Purpose: To define a metric for the separability between water and olefinic fat peaks that defines a threshold beyond which the extraction of the olefinic fat peak from vertebral bone marrow short-echo time-stimulated echo acquisition mode MRS at 3T is feasible when using a constrained peak fitting based on the triglyceride fat model. Methods: The water and olefinic peak height difference was defined as a metric for quantifying the separability of water and olefinic fat peaks. Fat unsaturation was determined using an unconstrained olefinic peak fitting and a constrained fitting of all fat peaks to the triglyceride model. The agreement between the two peak-fitting methods was used to define a threshold on water and olefinic peak height difference separating two groups (A and B), based on L5 short-echo time-stimulated echo acquisition mode (TE = 11 ms) spectra from 252 subjects measured at 3T. Results: A threshold on water and olefinic peak height difference was defined. Group A with a good agreement of the olefinic fat peak between the two peak-fitting methods showed a mean number of double bounds = 2.95 ± 0.21, a mean number of methylene-interrupted double bounds = 0.94 ± 0.16 and also a significantly lower coefficient of variation for all fatty acid composition parameters compared to group B (p <.001). The water and olefinic peak height difference value showed an inverse association with fat fraction. Conclusion: A threshold of a metric quantifying the separability of the water peak and the olefinic fat peaks was defined for the estimation of the vertebral bone marrow fat unsaturation from short-echo time-stimulated echo acquisition mode MRS. The proposed methodology shows that the assessment of vertebral bone marrow unsaturation is feasible with a short-echo time-stimulated echo acquisition mode MRS in subjects with a higher fat fraction.
Involved external institutions
Germany (DE)How to cite
APA:
Syvaeri, J., Ruschke, S., Dieckmeyer, M., Hauner, H.H., Junker, D., Makowski, M.R.,... Karampinos, D.C. (2021). Estimating vertebral bone marrow fat unsaturation based on short-TE STEAM MRS. Magnetic Resonance in Medicine, 85(2), 615-626. https://doi.org/10.1002/mrm.28453
MLA:
Syvaeri, Jan, et al. "Estimating vertebral bone marrow fat unsaturation based on short-TE STEAM MRS." Magnetic Resonance in Medicine 85.2 (2021): 615-626.
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