Dynamic contrast-enhanced MRI of prostate lesions of simultaneous [68 Ga]Ga-PSMA-11 PET/MRI: Comparison between intraprostatic lesions and correlation between perfusion parameters
Zhao J, Kader A, Mangarova DB, Brangsch J, Brenner W, Hamm B, Makowski MR (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 13
Pages Range: 1-12
Article Number: 1404
Journal Issue: 6
Abstract
We aimed to retrospectively compare the perfusion parameters measured from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) of prostate benign lesions and malignant lesions to determine the relationship between perfusion parameters. DCE-MRI was performed in patients with PCa who underwent simultaneous [68 Ga]Ga-prostate-specific membrane antigen (PSMA)-11 positron emission tomography (PET)/MRI. Six perfusion parameters (arrival time (AT), time to peak (TTP), wash-in slope (W-in), wash-out slope (W-out), peak enhancement intensity (PEI), and initial area under the 60-s curve (iAUC)), and a semi-quantitative parameter, standardized uptake values maximum (SUVmax) were calculated by placing regions of interest in the largest area of the lesions. The DCE-MRI parameters between prostate benign and malignant lesions were compared. The DCE-MRI parameters in both the benign and malignant lesions subgroup with SUVmax ≤ 3.0 and SUVmax > 3.0 were compared. The correlation of DCE-MRI parameters was investigated. Malignant lesions demonstrated significantly shorter TTP and higher SUVmax than did benign lesions. In the benign and malignant lesions subgroup, perfusion parameters of lesions with SUVmax ≤ 3.0 show no significant difference to those with SUVmax > 3.0. DCE-MRI perfusion parameters show a close correlation with each other. DCE-MRI parameters reflect the perfusion characteristics of intraprostatic lesions with malignant lesions, demonstrating significantly shorter TTP. There is a moderate to strong correlation between DCE-MRI parameters. Semi-quantitative analysis reflects that malignant lesions show a significantly higher SUVmax than benign lesions.
Involved external institutions
Germany (DE)How to cite
APA:
Zhao, J., Kader, A., Mangarova, D.B., Brangsch, J., Brenner, W., Hamm, B., & Makowski, M.R. (2021). Dynamic contrast-enhanced MRI of prostate lesions of simultaneous [68 Ga]Ga-PSMA-11 PET/MRI: Comparison between intraprostatic lesions and correlation between perfusion parameters. Cancers, 13(6), 1-12. https://doi.org/10.3390/cancers13061404
MLA:
Zhao, Jing, et al. "Dynamic contrast-enhanced MRI of prostate lesions of simultaneous [68 Ga]Ga-PSMA-11 PET/MRI: Comparison between intraprostatic lesions and correlation between perfusion parameters." Cancers 13.6 (2021): 1-12.
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