Parrotta EI, Procopio A, Scalise S, Esposito C, Nicoletta G, Santamaria G, De Angelis MT, Dorn T, Moretti A, Laugwitz KL, Montefusco F, Cosentino C, Cuda G (2021)
Publication Type: Journal article
Publication year: 2021
Book Volume: 22
Pages Range: 1-19
Article Number: 2004
Journal Issue: 4
DOI: 10.3390/ijms22042004
Arrhythmogenic Right Ventricular cardiomyopathy (ARVC) is an inherited cardiac muscle disease linked to genetic deficiency in components of the desmosomes. The disease is characterized by progressive fibro-fatty replacement of the right ventricle, which acts as a substrate for arrhythmias and sudden cardiac death. The molecular mechanisms underpinning ARVC are largely unknown. Here we propose a mathematical model for investigating the molecular dynamics underlying heart remodeling and the loss of cardiac myocytes identity during ARVC. Our methodology is based on three computational models: firstly, in the context of the Wnt pathway, we examined two different competition mechanisms between β-catenin and Plakoglobin (PG) and their role in the expression of adipogenic program. Secondly, we investigated the role of RhoA-ROCK pathway in ARVC pathogenesis, and thirdly we analyzed the interplay between Wnt and RhoA-ROCK pathways in the context of the ARVC phenotype. We conclude with the following remark: both Wnt/β-catenin and RhoA-ROCK pathways must be inactive for a significant increase of PPARγ expression, suggesting that a crosstalk mechanism might be responsible for mediating ARVC pathogenesis.
APA:
Parrotta, E.I., Procopio, A., Scalise, S., Esposito, C., Nicoletta, G., Santamaria, G.,... Cuda, G. (2021). Deciphering the role of wnt and rho signaling pathway in ipsc-derived arvc cardiomyocytes by in silico mathematical modeling. International Journal of Molecular Sciences, 22(4), 1-19. https://doi.org/10.3390/ijms22042004
MLA:
Parrotta, Elvira Immacolata, et al. "Deciphering the role of wnt and rho signaling pathway in ipsc-derived arvc cardiomyocytes by in silico mathematical modeling." International Journal of Molecular Sciences 22.4 (2021): 1-19.
BibTeX: Download