The discovAIR project: a roadmap towards the Human Lung Cell Atlas

Luecken MD, Zaragosi LE, Madissoon E, Sikkema L, Firsova AB, De Domenico E, Kuemmerle L, Saglam A, Berg M, Gay ACA, Schniering J, Mayr CH, Abalo XM, Larsson L, Sountoulidis A, Teichmann SA, Van Eunen K, Koppelman GH, Saeb-Parsy K, Leroy S, Powell P, Sarkans U, Timens W, Lundeberg J, Van Den Berge M, Nilsson M, Horvath P, Denning J, Papatheodorou I, Schultze JL, Schiller HB, Barbry P, Petoukhov I, Misharin AV, Adcock IM, Von Papen M, Theis FJ, Samakovlis C, Meyer KB, Nawijn MC (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Book Volume: 60

Article Number: 2102057

Journal Issue: 2

DOI: 10.1183/13993003.02057-2021

Abstract

The Human Cell Atlas (HCA) consortium aims to establish an atlas of all organs in the healthy human body at single-cell resolution to increase our understanding of basic biological processes that govern development, physiology and anatomy, and to accelerate diagnosis and treatment of disease. The Lung Biological Network of the HCA aims to generate the Human Lung Cell Atlas as a reference for the cellular repertoire, molecular cell states and phenotypes, and cell–cell interactions that characterise normal lung homeostasis in healthy lung tissue. Such a reference atlas of the healthy human lung will facilitate mapping the changes in the cellular landscape in disease. The discovAIR project is one of six pilot actions for the HCA funded by the European Commission in the context of the H2020 framework programme. discovAIR aims to establish the first draft of an integrated Human Lung Cell Atlas, combining single-cell transcriptional and epigenetic profiling with spatially resolving techniques on matched tissue samples, as well as including a number of chronic and infectious diseases of the lung. The integrated Human Lung Cell Atlas will be available as a resource for the wider respiratory community, including basic and translational scientists, clinical medicine, and the private sector, as well as for patients with lung disease and the interested lay public. We anticipate that the Human Lung Cell Atlas will be the founding stone for a more detailed understanding of the pathogenesis of lung diseases, guiding the design of novel diagnostics and preventive or curative interventions.

Involved external institutions

Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (HMGU) / Helmholtz Munich Germany (DE) University of Côte d'Azur / Université Côte d'Azur France (FR) Wellcome Trust Sanger Institute - Genome Research Limited United Kingdom (GB) Stockholm University / Stockholms universitet Sweden (SE) Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Germany (DE) University of Groningen / Rijksuniversiteit Groningen Netherlands (NL) University Medical Center Groningen (UMCG) / Universitair Medisch Centrum Groningen Netherlands (NL) University of Cambridge United Kingdom (GB) European Lung Foundation (ELF) United Kingdom (GB) The European Bioinformatics Institute (EBI) United Kingdom (GB) Royal Institute of Technology / Kungliga Tekniska Högskolan (KTH) Sweden (SE) Biological Research Centre (BRC) of the Hungarian Academy of Sciences / MTA Szegedi Biológiai Központ Hungary (HU) Northwestern University United States (USA) (US) Imperial College London / The Imperial College of Science, Technology and Medicine United Kingdom (GB) Comma Soft AG Germany (DE)

How to cite

APA:

Luecken, M.D., Zaragosi, L.-E., Madissoon, E., Sikkema, L., Firsova, A.B., De Domenico, E.,... Nawijn, M.C. (2022). The discovAIR project: a roadmap towards the Human Lung Cell Atlas. European Respiratory Journal, 60(2). https://doi.org/10.1183/13993003.02057-2021

MLA:

Luecken, Malte D., et al. "The discovAIR project: a roadmap towards the Human Lung Cell Atlas." European Respiratory Journal 60.2 (2022).

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