Intraoperative imaging in pathology-assisted surgery

Voskuil FJ, Vonk J, Van Der Vegt B, Kruijff S, Ntziachristos V, Van Der Zaag PJ, Witjes MJH, Van Dam GM (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Nature Biomedical Engineering Nature Research

Book Volume: 6

Pages Range: 503-514

Journal Issue: 5

DOI: 10.1038/s41551-021-00808-8

Abstract

The pathological assessment of surgical specimens during surgery can reduce the incidence of positive resection margins, which otherwise can result in additional surgeries or aggressive therapeutic regimens. To improve patient outcomes, intraoperative spectroscopic, fluorescence-based, structural, optoacoustic and radiological imaging techniques are being tested on freshly excised tissue. The specific clinical setting and tumour type largely determine whether endogenous or exogenous contrast is to be detected and whether the tumour specificity of the detected biomarker, image resolution, image-acquisition times or penetration depth are to be prioritized. In this Perspective, we describe current clinical standards for intraoperative tissue analysis and discuss how intraoperative imaging is being implemented. We also discuss potential implementations of intraoperative pathology-assisted surgery for clinical decision-making.

Involved external institutions

University of Groningen / Rijksuniversiteit Groningen NL Netherlands (NL) Technische Universität München (TUM) DE Germany (DE)

How to cite

APA:

Voskuil, F.J., Vonk, J., Van Der Vegt, B., Kruijff, S., Ntziachristos, V., Van Der Zaag, P.J.,... Van Dam, G.M. (2022). Intraoperative imaging in pathology-assisted surgery. Nature Biomedical Engineering, 6(5), 503-514. https://doi.org/10.1038/s41551-021-00808-8

MLA:

Voskuil, Floris J., et al. "Intraoperative imaging in pathology-assisted surgery." Nature Biomedical Engineering 6.5 (2022): 503-514.

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