Simultaneous [18F]fluoride and gadobutrol enhanced coronary positron emission tomography/magnetic resonance imaging for in vivo plaque characterization
Wurster TH, Landmesser U, Abdelwahed YS, Skurk C, Morguet A, Leistner DM, Froehlich G, Haghikia A, Engel LC, Schuster A, Noutsias M, Schulze D, Hamm B, Furth C, Brenner W, Botnar RM, Bigalke B, Makowski MR (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 23
Pages Range: 1391-1398
Journal Issue: 10
Abstract
AIMS: 18F-sodium fluoride ([18F]fluoride) and gadobutrol are promising probes for positron emission tomography (PET) and magnetic resonance imaging (MRI) characterizing coronary artery disease (CAD) activity. Unlike [18F]fluoride-PET/computed tomography (CT), the potential of PET/MR using [18F]fluoride and gadobutrol simultaneously, has so far not been evaluated. This study assessed feasibility and diagnostic potential of [18F]fluoride and gadobutrol enhanced dual-probe PET/MR in patients with CAD. METHODS AND RESULTS: Twenty-one patients (age, 66.7 ± 6.7 years) with CAD scheduled for invasive coronary angiography (XCA) underwent simultaneous [18F]fluoride (mean activity/effective dose: 157.2 ± 29.7 MBq/3.77 ± 0.72 mSv) and gadobutrol enhanced PET/MR on an integrated PET/MRI (3 T) scanner. Optical coherence tomography (OCT) was used as reference. Target-to-background ratio (TBR, [18F]fluoride-PET) and contrast-to-noise ratio (CNR) values (MRI, gadobutrol) were calculated for each coronary segment. Previously suggested PET/CT-TBR thresholds for adverse coronary events were evaluated. High-risk plaques, i.e. calcified and non-calcified thin-cap fibroatheromas (TCFAs) were predominantly located in segments with a TBR >1.28 (P = 0.012). Plaques containing a lipid core on OCT, were more frequently detected in segments with a TBR >1.25 (P < 0.001). TBR values significantly correlated with maximum calcification thickness (P = 0.009), while fibrous cap thickness was significantly less in segments with a TBR >1.28 (P = 0.044). Above a TBR threshold of >1.28, CNR values significantly correlated with the presence of calcified TCFAs (P = 0.032). CONCLUSION: Simultaneous [18F]fluoride and gadobutrol dual-probe PET/MRI is feasible in clinical practice and may facilitate the identification of high-risk patients. The combination of coronary MR-derived CNR values post gadobutrol and [18F]fluoride based TBR values may improve identification of high-risk plaque features.
Involved external institutions
Charité - Universitätsmedizin Berlin
Germany (DE)
Martin-Luther-Universität Halle-Wittenberg (MLU)
Germany (DE)
Berliner Institut für Gesundheitsforschung (BIH)
Germany (DE)
King’s College London
United Kingdom (GB)
Georg-August-Universität Göttingen
Germany (DE)
Germany (DE)
Martin-Luther-Universität Halle-Wittenberg (MLU)
Germany (DE)
Berliner Institut für Gesundheitsforschung (BIH)
Germany (DE)
King’s College London
United Kingdom (GB)
Georg-August-Universität Göttingen
Germany (DE)
How to cite
APA:
Wurster, T.H., Landmesser, U., Abdelwahed, Y.S., Skurk, C., Morguet, A., Leistner, D.M.,... Makowski, M.R. (2022). Simultaneous [18F]fluoride and gadobutrol enhanced coronary positron emission tomography/magnetic resonance imaging for in vivo plaque characterization. European Heart Journal - Cardiovascular Imaging, 23(10), 1391-1398. https://doi.org/10.1093/ehjci/jeab276
MLA:
Wurster, Thomas H., et al. "Simultaneous [18F]fluoride and gadobutrol enhanced coronary positron emission tomography/magnetic resonance imaging for in vivo plaque characterization." European Heart Journal - Cardiovascular Imaging 23.10 (2022): 1391-1398.
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