Ten-year patterns of stent thrombosis after percutaneous coronary intervention with new- versus early-generation drug-eluting stents: insights from the DECADE cooperation Trombosis del stent 10 años después de la intervención coronaria percutánea con stents nuevos frente a stents de la primera generación. Observaciones del metanálisis DECADE

Coughlan JJ, Maeng M, Räber L, Brugaletta S, Aytekin A, Okkels Jensen L, Bär S, Ortega-Paz L, Laugwitz KL, Madsen M, Heg D, Sabaté M, Kufner S, Warnakula Olesen KK, Kastrati A, Windecker S, Cassese S (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Revista Espanola De Cardiologia Elsevier España (Elsevier Doyma) / Sociedad Española de Cardiología

Book Volume: 75

Pages Range: 897-905

Journal Issue: 11

DOI: 10.1016/j.recesp.2022.02.003

Abstract

Introduction and objectives: The DECADE cooperation is a pooled analysis of individual patient data from drug-eluting stent (DES) trials with a 10-year follow-up. This analysis reports the risk of definite stent thrombosis (ST) through to 10 years after percutaneous coronary intervention (PCI) in patients treated with early- and new-generation DES. Methods: Individual patient data from 5 DES trials with a 10-year follow-up were pooled. The primary endpoint was definite ST up to 10 years after PCI. Patients were divided into 2 groups as per the generation of DES implanted (early and new DES). Individual participant data were analyzed using a 1-stage approach. Results: We included 9700 patients, 6866 in the new DES group and 2834 in the early DES group. Through to 10 years, definite ST occurred in 69 of 6866 patients treated with new DES and in 91 of 2834 patients treated with early DES (1.0% vs 3.5%, adjusted hazard ratio, 0.32; 95%CI, 0.23-0.45). The rate of definite ST was lower in the new DES group than in the early DES group from 1 to 5 years (rate ratio, 0.14; 95%CI, 0.08-0.26) and from 5 to 10 years (rate ratio, 0.23; 95%CI, 0.08-0.61) after PCI. Conclusions: The incidence of definite ST through to 10 years after PCI with new-generation DES was 1%. New-generation DES are associated with a lower 10-year incidence of definite ST than early-generation DES, particularly beyond 1 year after PCI.

Involved external institutions

Klinikum rechts der Isar DE Germany (DE) Aarhus University Hospital / Aarhus Universitetshospital DK Denmark (DK) Inselspital, Universitätsspital Bern CH Switzerland (CH) Universitat de Barcelona (UB) / University of Barcelona ES Spain (ES) Technische Universität München (TUM) DE Germany (DE) Odense Universitetshospital (OUH) DK Denmark (DK)

How to cite

APA:

Coughlan, J.J., Maeng, M., Räber, L., Brugaletta, S., Aytekin, A., Okkels Jensen, L.,... Cassese, S. (2022). Ten-year patterns of stent thrombosis after percutaneous coronary intervention with new- versus early-generation drug-eluting stents: insights from the DECADE cooperation Trombosis del stent 10 años después de la intervención coronaria percutánea con stents nuevos frente a stents de la primera generación. Observaciones del metanálisis DECADE. Revista Espanola De Cardiologia, 75(11), 897-905. https://doi.org/10.1016/j.recesp.2022.02.003

MLA:

Coughlan, John Joseph, et al. "Ten-year patterns of stent thrombosis after percutaneous coronary intervention with new- versus early-generation drug-eluting stents: insights from the DECADE cooperation Trombosis del stent 10 años después de la intervención coronaria percutánea con stents nuevos frente a stents de la primera generación. Observaciones del metanálisis DECADE." Revista Espanola De Cardiologia 75.11 (2022): 897-905.

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