Multi-modal functional MRI to explore placental function over gestation
Hutter J, Slator PJ, Jackson L, Gomes ADS, Ho A, Story L, O'Muircheartaigh J, Teixeira RPAG, Chappell LC, Alexander DC, Rutherford MA, Hajnal JV (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 81
Pages Range: 1191-1204
Journal Issue: 2
DOI: 10.1002/mrm.27447
Abstract
Purpose: To investigate, visualize and quantify the physiology of the human placenta in several dimensions - functional, temporal over gestation, and spatial over the whole organ. Methods: Bespoke MRI techniques, combining a rich diffusion protocol, anatomical data and T2* mapping together with a multi-modal pipeline including motion correction and extracted quantitative features were developed and employed on pregnant women between 22 and 38 weeks gestational age including two pregnancies diagnosed with pre-eclampsia. Results: A multi-faceted assessment was demonstrated showing trends of increasing lacunarity, and decreasing T2* and diffusivity over gestation. Conclusions: The obtained multi-modal acquisition and quantification shows promising opportunities for studying evolution, adaptation and compensation processes.
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United Kingdom (GB)How to cite
APA:
Hutter, J., Slator, P.J., Jackson, L., Gomes, A.D.S., Ho, A., Story, L.,... Hajnal, J.V. (2019). Multi-modal functional MRI to explore placental function over gestation. Magnetic Resonance in Medicine, 81(2), 1191-1204. https://doi.org/10.1002/mrm.27447
MLA:
Hutter, Jana, et al. "Multi-modal functional MRI to explore placental function over gestation." Magnetic Resonance in Medicine 81.2 (2019): 1191-1204.
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