The Relevance of Hemolysis in Anesthesia and Intensive Care Medicine Die Bedeutung der Hämolyse in Anästhesie und Intensivmedizin
Graw JA, Baron DM, Francis RCE (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 53
Pages Range: 296-305
Journal Issue: 4
Abstract
Hemolysis leads to an increase of circulating intravascular cell-free hemoglobin. Increased plasma concentrations of cell-free hemoglobin are relevant in critically ill patients because cell-free hemoglobin causes vasoconstriction by depletion of endothelial nitric oxide, oxidative stress, and inflammation. Furthermore, cell-free hemoglobin contributes to tissue injuries such as renal failure and intestinal mucosa damage after cardiac surgery. High concentrations of cell-free hemoglobin are associated with an increased mortality in patients with sepsis. Currently, it is unclear if hemolysis associated with transfusion of packed red blood cells that have been stored for prolonged periods of time is relevant for the clinical outcome. However, humans possess plasma proteins haptoglobin and hemopexin which bind to plasma hemoglobin and cell-free heme, respectively. The haptoglobin-hemoglobin and hemopexin-heme complexes are then eliminated from the plasma by hepatic or splenic uptake.
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Germany (DE)How to cite
APA:
Graw, J.A., Baron, D.M., & Francis, R.C.E. (2018). The Relevance of Hemolysis in Anesthesia and Intensive Care Medicine Die Bedeutung der Hämolyse in Anästhesie und Intensivmedizin. AINS - Anästhesiologie. Intensivmedizin. Notfallmedizin. Schmerztherapie., 53(4), 296-305. https://doi.org/10.1055/s-0043-121622
MLA:
Graw, Jan A., David M. Baron, and Roland C. E. Francis. "The Relevance of Hemolysis in Anesthesia and Intensive Care Medicine Die Bedeutung der Hämolyse in Anästhesie und Intensivmedizin." AINS - Anästhesiologie. Intensivmedizin. Notfallmedizin. Schmerztherapie. 53.4 (2018): 296-305.
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