Molecular Parameters Promoting High Relaxivity in Cluster-Nanocarrier Magnetic Resonance Imaging Contrast Agents

Lyons T, Kekedjian C, Glaser P, Ohlin CA, van Eldik R, Rodriguez O, Albanese C, Van Keuren E, Stoll SL (2022)

Publication Type: Journal article

Publication year: 2022

Journal

ACS Applied Materials and Interfaces American Chemical Society

DOI: 10.1021/acsami.2c12584

Abstract

We have investigated the mechanism of relaxivity for two magnetic resonance imaging contrast agents that both employ a cluster-nanocarrier design. The first system termed Mn8Fe4-coPS comprises the cluster Mn8Fe4O12(L)16(H2O)4or Mn8Fe4(1) (L = carboxylate) co-polymerized with polystyrene to form ∼75 nm nanobeads. The second system termed Mn3Bpy-PAm used the cluster Mn3(O2CCH3)6(Bpy)2or Mn3Bpy (2) where Bpy = 2,2′-bipyridine, entrapped in ∼180 nm polyacrylamide nanobeads. Here, we investigate the rate of water exchange of the two clusters, and corresponding cluster-nanocarriers, in order to elucidate the mechanism of relaxivity in the cluster-nanocarrier. Swift-Connick analysis of O-17 NMR was used to determine the water exchange rates of the clusters and cluster-nanocarriers. We found distinct differences in the water exchange rate between Mn8Fe4and Mn8Fe4-coPS, and we utilized these differences to elucidate the nanobead structure. Using the transverse relaxivity from O-17 NMR line widths, we were able to determine the hydration state of the Mn3Bpy (2) cluster as well as Mn3Bpy-PAm. Using these hydration states in the Swift-Connick analysis of O-17 NMR, we found the water exchange rate to be extremely close in value for the cluster Mn3Bpy and cluster-nanocarrier Mn3Bpy-PAm.

Authors with CRIS profile

Rudi van Eldik Naturwissenschaftliche Fakultät

Involved external institutions

Georgetown University US United States (USA) (US) Umeå University SE Sweden (SE) Georgetown Lombardi Comprehensive Cancer Center US United States (USA) (US)

How to cite

APA:

Lyons, T., Kekedjian, C., Glaser, P., Ohlin, C.A., van Eldik, R., Rodriguez, O.,... Stoll, S.L. (2022). Molecular Parameters Promoting High Relaxivity in Cluster-Nanocarrier Magnetic Resonance Imaging Contrast Agents. ACS Applied Materials and Interfaces. https://doi.org/10.1021/acsami.2c12584

MLA:

Lyons, Trevor, et al. "Molecular Parameters Promoting High Relaxivity in Cluster-Nanocarrier Magnetic Resonance Imaging Contrast Agents." ACS Applied Materials and Interfaces (2022).

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