Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections

Paprckova D, Niederlova V, Moudra A, Drobek A, Pribikova M, Janusova S, Schober K, Neuwirth A, Michalik J, Huranova M, Horkova V, Cesnekova M, Simova M, Prochazka J, Balounova J, Busch DH, Sedlacek R, Schwarzer M, Stepanek O (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Frontiers in Immunology Frontiers Research Foundation / Frontiers Media

Book Volume: 13

Article Number: 1009198

DOI: 10.3389/fimmu.2022.1009198

Abstract

Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important factors regulating their fate and immune response, but the role of self-reactivity in T-cell biology is incompletely understood. We addressed the role of self-reactivity in T-cell diversity by generating an atlas of mouse peripheral CD8+ T cells, which revealed two unconventional populations of antigen-inexperienced T cells. In the next step, we examined the steady-state phenotype of monoclonal T cells with various levels of self-reactivity. Highly self-reactive clones preferentially differentiate into antigen-inexperienced memory-like cells, but do not form a population expressing type I interferon-induced genes, showing that these two subsets have unrelated origins. The functional comparison of naïve monoclonal CD8+ T cells specific to the identical model antigen did not show any correlation between the level of self-reactivity and the magnitude of the immune response.

Authors with CRIS profile

Kilian Schober Institute of Microbiology – Clinical Microbiology, Immunology and Hygiene

Involved external institutions

Academy of Sciences of the Czech Republic (ASCR) / Akademie věd České republiky (AVČR) CZ Czech Republic (CZ) Technische Universität München (TUM) DE Germany (DE)

How to cite

APA:

Paprckova, D., Niederlova, V., Moudra, A., Drobek, A., Pribikova, M., Janusova, S.,... Stepanek, O. (2022). Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections. Frontiers in Immunology, 13. https://doi.org/10.3389/fimmu.2022.1009198

MLA:

Paprckova, Darina, et al. "Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections." Frontiers in Immunology 13 (2022).

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