At the Heart of Eosinophilic Granulomatosis with Polyangiitis: into Cardiac and Vascular Involvement

Bond M, Fagni F, Moretti M, Bello F, Egan A, Vaglio A, Emmi G, Dejaco C (2022)

Publication Type: Journal article, Review article

Publication year: 2022

Journal

Current Rheumatology Reports Current Science Inc.

Book Volume: 24

Pages Range: 337-351

Journal Issue: 11

DOI: 10.1007/s11926-022-01087-1

Abstract

Purpose of Review: To provide an overview of existing literature on pathogenetic and clinical aspects of cardiac and vascular involvement in eosinophilic granulomatosis with polyangiitis (EGPA). Recent Findings: In EGPA, cardiac and vascular involvement are more common than previously thought. However, no international recommendations on the topic are available yet. Herein, we summarize the existing evidence on the topic and propose a diagnostic approach for cardiac involvement in EGPA. Summary: The prevalence of cardiovascular involvement in patients with EGPA varies greatly among published studies, ranging between 3.1–18.7% for occlusive arterial disease, 5.8–30% for venous thrombosis and 17–92% for heart involvement. Cardiac involvement in EGPA is associated with high mortality even though manifestations are heterogeneous. In principle, every anatomical structure of the heart can be involved, and EGPA-related heart disease may be completely asymptomatic at first. A careful diagnostic work-up for early detection and prompt treatment initiation is therefore required. While cardiac manifestations are more common in anti-neutrophil cytoplasmic antibodies (ANCA)-negative patients, arterial and venous thrombotic events are not linked to ANCA status but correlate closely with disease activity and accumulate at disease onset. Thrombotic events (mainly venous) are considerably more frequent in EGPA than in the general population contributing substantially to morbidity and highlighting the importance of developing specific prevention strategies for patients who are diagnosed with EGPA.

Authors with CRIS profile

Filippo Fagni Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

Krankenhaus Bruneck / Ospedale di Brunico IT Italy (IT) Azienda Provinciale per i Servizi Sanitari IT Italy (IT) Università degli Studi di Firenze / University of Florence IT Italy (IT) Addenbrooke's Hospital GB United Kingdom (GB) Azienda Ospedaliera Universitaria Meyer IT Italy (IT)

How to cite

APA:

Bond, M., Fagni, F., Moretti, M., Bello, F., Egan, A., Vaglio, A.,... Dejaco, C. (2022). At the Heart of Eosinophilic Granulomatosis with Polyangiitis: into Cardiac and Vascular Involvement. Current Rheumatology Reports, 24(11), 337-351. https://doi.org/10.1007/s11926-022-01087-1

MLA:

Bond, Milena, et al. "At the Heart of Eosinophilic Granulomatosis with Polyangiitis: into Cardiac and Vascular Involvement." Current Rheumatology Reports 24.11 (2022): 337-351.

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