Crypts in Asymmetric Branching in Patients With Ulcerative Colitis in Remission

Rubio CA, Vieth M, Lang-Schwarz C (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Anticancer Research International Institute of Anticancer Research (IIAR)

Book Volume: 42

Pages Range: 4493-4497

Journal Issue: 9

DOI: 10.21873/anticanres.15950

Abstract

BACKGROUND/AIM: To report the frequency of crypts in asymmetric branching (CAB) in biopsies from all colorectal segments in patients with ulcerative colitis in remission (UCR). PATIENTS AND METHODS: Biopsies in 100 UC patients were investigated: 50 with UCR and 50 with ongoing long-lasting UC (LLU; i.e., controls). RESULTS: The frequency of CAB was significantly lower in UCR than in LLUC, both in the right colon and left colorectum. CAB frequency was not influenced by two important confounders: the age and sex of patients. CONCLUSION: CAB is a pathologic aberration of colorectal cryptogenesis evoked by chronic mucosal inflammation. When chronic inflammation waned in UCR, the production of CAB plummeted or ceased. Chronic inflammation and protracted disease-duration in LLUC increase the risk for colorectal dysplasia or carcinoma. Importantly, dysplastic CAB were recently detected in LLUC-associated dysplasia. Whether the abrogation of CAB is instrumental in reducing the neoplastic risk in UCR patients, deserves further investigation.

Authors with CRIS profile

Michael Vieth Professur für Allgemeine Pathologie

Involved external institutions

Klinikum Bayreuth DE Germany (DE) Karolinska Institute SE Sweden (SE)

How to cite

APA:

Rubio, C.A., Vieth, M., & Lang-Schwarz, C. (2022). Crypts in Asymmetric Branching in Patients With Ulcerative Colitis in Remission. Anticancer Research, 42(9), 4493-4497. https://doi.org/10.21873/anticanres.15950

MLA:

Rubio, Carlos A., Michael Vieth, and Corinna Lang-Schwarz. "Crypts in Asymmetric Branching in Patients With Ulcerative Colitis in Remission." Anticancer Research 42.9 (2022): 4493-4497.

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