Normative quantitative relaxation atlases for characterization of cortical regions using magnetic resonance fingerprinting

Choi JY, Hu S, Su TY, Murakami H, Tang Y, Blumcke I, Najm I, Sakaie K, Jones S, Griswold M, Wang ZI, Ma D (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Cerebral Cortex Oxford University Press

DOI: 10.1093/cercor/bhac292

Abstract

Quantitative magnetic resonance (MR) has been used to study cyto- and myelo-architecture of the human brain non-invasively. However, analyzing brain cortex using high-resolution quantitative MR acquisition can be challenging to perform using 3T clinical scanners. MR fingerprinting (MRF) is a highly efficient and clinically feasible quantitative MR technique that simultaneously provides T-1 and T-2 relaxation maps. Using 3D MRF from 40 healthy subjects (mean age = 25.6 +/- 4.3 years) scanned on 3T magnetic resonance imaging, we generated whole-brain gyral-based normative MR relaxation atlases and investigated cortical-region-based T-1 and T-2 variations. Gender and age dependency of T-1 and T-2 variations were additionally analyzed. The coefficient of variation of T-1 and T-2 for each cortical-region was 3.5% and 7.3%, respectively, supporting low variability of MRF measurements across subjects. Significant differences in T-1 and T-2 were identified among 34 brain regions (P < 0.001), lower in the precentral, postcentral, paracentral lobule, transverse temporal, lateral occipital, and cingulate areas, which contain sensorimotor, auditory, visual, and limbic functions. Significant correlations were identified between age and T-1 and T-2 values. This study established whole-brain MRF T-1 and T-2 atlases of healthy subjects using a clinical 3T scanner, which can provide a quantitative and region-specific baseline for future brain studies and pathology detection.

Involved external institutions

Cleveland Clinic US United States (USA) (US) Case Western Reserve University US United States (USA) (US)

How to cite

APA:

Choi, J.Y., Hu, S., Su, T.-Y., Murakami, H., Tang, Y., Blumcke, I.,... Ma, D. (2022). Normative quantitative relaxation atlases for characterization of cortical regions using magnetic resonance fingerprinting. Cerebral Cortex. https://doi.org/10.1093/cercor/bhac292

MLA:

Choi, Joon Yul, et al. "Normative quantitative relaxation atlases for characterization of cortical regions using magnetic resonance fingerprinting." Cerebral Cortex (2022).

BibTeX: Download