Highly pigmented Tg(Grm1) mouse melanoma develops non-pigmented melanoma cells in distant metastases

Schiffner S, Chen S, Becker JC, Bosserhoff AK (2012)

Publication Type: Journal article

Publication year: 2012

Journal

Experimental Dermatology Wiley

Book Volume: 21

Pages Range: 786-788

Journal Issue: 10

DOI: 10.1111/j.1600-0625.2012.01560.x

Abstract

Murine model systems are critically required tools for the investigation of unknown mechanisms of melanoma development and metastasis and for developing more efficient therapies. The Tg(Grm1)EPv melanoma mouse model is characterized by spontaneous development of pigmented cutaneous melanomas at hairless skin regions, with a short latency and 100% penetrance. Local metastasis was described in initial analyses; however, melanoma cells were not observed in distant organs. Here, we demonstrate that the established Tg(Grm1)EPv melanoma mouse model exhibits more extensive metastasis into distant organs than previously described. Disseminated cells undergo phenotypic changes, as we observed high numbers of non-pigmented Grm1-expressing melanoma cells within distant organs. As such changes during metastasis are common in human melanoma, our findings demonstrate that this mouse model represents an even more useful tool to study unknown mechanisms of metastasis in human melanoma than previously assumed. © 2012 John Wiley & Sons A/S.

Involved external institutions

Universität Regensburg DE Germany (DE) The State University of New Jersey (Rutgers) US United States (USA) (US)

How to cite

APA:

Schiffner, S., Chen, S., Becker, J.C., & Bosserhoff, A.-K. (2012). Highly pigmented Tg(Grm1) mouse melanoma develops non-pigmented melanoma cells in distant metastases. Experimental Dermatology, 21(10), 786-788. https://doi.org/10.1111/j.1600-0625.2012.01560.x

MLA:

Schiffner, Susanne, et al. "Highly pigmented Tg(Grm1) mouse melanoma develops non-pigmented melanoma cells in distant metastases." Experimental Dermatology 21.10 (2012): 786-788.

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