Central nervous system infiltrates are characterized by features of ongoing B cell-related immune activity in MP4-induced experimental autoimmune encephalomyelitis

Batoulis H, Wunsch M, Birkenheier J, Rottlaender A, Gorboulev V, Kuerten S (2015)

Publication Type: Journal article

Publication year: 2015

Journal

Clinical Immunology Elsevier

Book Volume: 158

Pages Range: 47-58

Journal Issue: 1

DOI: 10.1016/j.clim.2015.03.009

Abstract

In multiple sclerosis (MS) lymphoid follicle-like aggregates have been reported in the meninges of patients. Here we investigated the functional relevance of B cell infiltration into the central nervous system (CNS) in MP4-induced experimental autoimmune encephalomyelitis (EAE), a B cell-dependent mouse model of MS. In chronic EAE, B cell aggregates were characterized by the presence of CXCL13+ and germinal center CD10+ B cells. Germline transcripts were expressed in the CNS and particularly related to TH17-associated isotypes. We also observed B cells with restricted VH gene usage that differed from clones found in the spleen. Finally, we detected CNS-restricted spreading of the antigen-specific B cell response towards a myelin and a neuronal autoantigen. These data imply the development of autonomous B cell-mediated autoimmunity in the CNS in EAE - a concept that might also apply to MS itself.

Authors with CRIS profile

Stefanie Kürten

Involved external institutions

Universität zu Köln DE Germany (DE) Julius-Maximilians-Universität Würzburg DE Germany (DE)

How to cite

APA:

Batoulis, H., Wunsch, M., Birkenheier, J., Rottlaender, A., Gorboulev, V., & Kuerten, S. (2015). Central nervous system infiltrates are characterized by features of ongoing B cell-related immune activity in MP4-induced experimental autoimmune encephalomyelitis. Clinical Immunology, 158(1), 47-58. https://doi.org/10.1016/j.clim.2015.03.009

MLA:

Batoulis, Helena, et al. "Central nervous system infiltrates are characterized by features of ongoing B cell-related immune activity in MP4-induced experimental autoimmune encephalomyelitis." Clinical Immunology 158.1 (2015): 47-58.

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