Feasibility of Intestinal MR Elastography in Inflammatory Bowel Disease
Reiter R, Loch FN, Kamphues C, Bayerl C, Garcia SRM, Siegmund B, Kuehl AA, Hamm B, Braun J, Sack I, Asbach P (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 55
Pages Range: 815-822
Journal Issue: 3
DOI: 10.1002/jmri.27833
Abstract
Background: While MR enterography allows detection of inflammatory bowel disease (IBD), the findings continue to be of limited use in guiding treatment—medication vs. surgery. Purpose: To test the feasibility of MR elastography of the gut in healthy volunteers and IBD patients. Study Type: Prospective pilot. Population: Forty subjects (healthy volunteers: n = 20, 37 ± 14 years, 10 women; IBD patients: n = 20 (ulcerative colitis n = 9, Crohn's disease n = 11), 41 ± 15 years, 11 women). Field Strength/Sequence: Multifrequency MR elastography using a single-shot spin-echo echo planar imaging sequence at 1.5 T with drive frequencies of 40, 50, 60, and 70 Hz. Assessment: Maps of shear-wave speed (SWS, in m/s) and loss angle (φ, in rad), representing stiffness and solid–fluid behavior, respectively, were generated using tomoelastography data processing. Histopathological analysis of surgical specimens was used as reference standard in patients. Statistical Tests: Unpaired t-test, one-way analysis of variance followed by Tukey post hoc analysis, Pearson's correlation coefficient and area under the receiver operating characteristic curve (AUC) with 95%-confidence interval (CI). Significance level of 5%. Results: MR elastography was feasible in all 40 subjects (100% technical success rate). SWS and φ were significantly increased in IBD by 21% and 20% (IBD: 1.45 ± 0.14 m/s and 0.78 ± 0.12 rad; healthy volunteers: 1.20 ± 0.14 m/s and 0.65 ± 0.06 rad), whereas no significant differences were found between ulcerative colitis and Crohn's disease (P = 0.74 and 0.90, respectively). In a preliminary assessment, a high diagnostic accuracy in detecting IBD was suggested by an AUC of 0.90 (CI: 0.81–0.96) for SWS and 0.84 (CI: 0.71–0.95) for φ. Data Conclusion: In this pilot study, our results demonstrated the feasibility of MR elastography of the gut and showed an excellent diagnostic performance in predicting IBD. Evidence Level: 1. Technical Efficacy: Stage 1.
Involved external institutions
Germany (DE)How to cite
APA:
Reiter, R., Loch, F.N., Kamphues, C., Bayerl, C., Garcia, S.R.M., Siegmund, B.,... Asbach, P. (2022). Feasibility of Intestinal MR Elastography in Inflammatory Bowel Disease. Journal of Magnetic Resonance Imaging, 55(3), 815-822. https://doi.org/10.1002/jmri.27833
MLA:
Reiter, Rolf, et al. "Feasibility of Intestinal MR Elastography in Inflammatory Bowel Disease." Journal of Magnetic Resonance Imaging 55.3 (2022): 815-822.
BibTeX: Download