Separation of fluid and solid shear wave fields and quantification of coupling density by magnetic resonance poroelastography

Lilaj L, Fischer T, Guo J, Braun J, Sack I, Hirsch S (2021)

Publication Type: Journal article

Publication year: 2021

Journal

Magnetic Resonance in Medicine Wiley

Book Volume: 85

Pages Range: 1655-1668

Journal Issue: 3

DOI: 10.1002/mrm.28507

Abstract

Purpose: Biological soft tissues often have a porous architecture comprising fluid and solid compartments. Upon displacement through physiological or externally induced motion, the relative motion of these compartments depends on poroelastic parameters, such as coupling density ((Formula presented.)) and tissue porosity. This study introduces inversion recovery MR elastography (IR-MRE) (1) to quantify porosity defined as fluid volume over total volume, (2) to separate externally induced shear strain fields of fluid and solid compartments, and (3) to quantify coupling density assuming a biphasic behavior of in vivo brain tissue. Theory and Methods: Porosity was measured in eight tofu phantoms and gray matter (GM) and white matter (WM) of 21 healthy volunteers. Porosity of tofu was compared to values obtained by fluid draining and microscopy. Solid and fluid shear-strain amplitudes and (Formula presented.) were estimated both in phantoms and in in vivo brain. Results: T1-based measurement of tofu porosity agreed well with reference values (R = 0.99, P <.01). Brain tissue porosity was 0.14 ± 0.02 in GM and 0.05 ± 0.01 in WM (P <.001). Fluid shear strain was found to be phase-locked with solid shear strain but had lower amplitudes in both tofu phantoms and brain tissue (P <.05). In accordance with theory, tofu and brain (Formula presented.) were negative. Conclusion: IR-MRE allowed for the first time separation of shear strain fields of solid and fluid compartments for measuring coupling density according to the biphasic theory of poroelasticity. Thus, IR-MRE opens horizons for poroelastography-derived imaging markers that can be used in basic research and diagnostic applications.

Involved external institutions

Charité - Universitätsmedizin Berlin DE Germany (DE)

How to cite

APA:

Lilaj, L., Fischer, T., Guo, J., Braun, J., Sack, I., & Hirsch, S. (2021). Separation of fluid and solid shear wave fields and quantification of coupling density by magnetic resonance poroelastography. Magnetic Resonance in Medicine, 85(3), 1655-1668. https://doi.org/10.1002/mrm.28507

MLA:

Lilaj, Ledia, et al. "Separation of fluid and solid shear wave fields and quantification of coupling density by magnetic resonance poroelastography." Magnetic Resonance in Medicine 85.3 (2021): 1655-1668.

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