Tomoelastography for the Evaluation of Pediatric Nonalcoholic Fatty Liver Disease
Hudert CA, Tzschaetzsch H, Rudolph B, Blaekey H, Loddenkemper C, Mueller HP, Henning S, Bufler P, Hamm B, Braun J, Holzhuetter HG, Wiegand S, Sack I, Guo J (2019)
Publication Type: Journal article
Publication year: 2019
Journal
Book Volume: 54
Pages Range: 198-203
Journal Issue: 4
DOI: 10.1097/RLI.0000000000000529
Abstract
Objectives Today, nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children and adults alike. Yet, the noninvasive evaluation of disease severity remains a diagnostic challenge. In this study, we apply multifrequency magnetic resonance elastography (mMRE) for the quantification of liver steatosis and fibrosis in adolescents with NAFLD. Methods Fifty adolescents (age range, 10-17 years; mean BMI, 33.9 kg/m2; range, 21.4-42.1 kg/m2) with biopsy-proven NAFLD were included in this prospective study. Multifrequency magnetic resonance elastography was performed using external multifrequency vibrations of 30 to 60 Hz and tomoelastography postprocessing, resulting in penetration rate (a) and shear wave speed (c). Hepatic fat fraction was determined using Dixon method. The diagnostic accuracy of mMRE in grading liver steatosis and staging liver fibrosis was assessed by receiver operating characteristic curve analysis. Results Multifrequency magnetic resonance elastography parameters c and a were independently sensitive to fibrosis and steatosis, respectively, providing area under the receiver operating characteristic values of 0.79 (95% confidence interval [CI], 0.66-0.92), 0.91 (95% CI, 0.83-0.99), and 0.90 (95% CI, 0.80-0.99) for the detection of any (≥F1), moderate (≥F2), and advanced (≥F3) fibrosis, and 0.87 (95% CI, 0.76-0.97) and 0.87 (95% CI, 0.77-0.96) for the detection of moderate (≥S2) and severe (S3) steatosis. Conclusions One mMRE measurement provides 2 independent parameters with very good diagnostic accuracy in detecting moderate and advanced fibrosis as well as moderate and severe steatosis in pediatric NAFLD.
Involved external institutions
Germany (DE)How to cite
APA:
Hudert, C.A., Tzschaetzsch, H., Rudolph, B., Blaekey, H., Loddenkemper, C., Mueller, H.-P.,... Guo, J. (2019). Tomoelastography for the Evaluation of Pediatric Nonalcoholic Fatty Liver Disease. Investigative Radiology, 54(4), 198-203. https://doi.org/10.1097/RLI.0000000000000529
MLA:
Hudert, Christian A., et al. "Tomoelastography for the Evaluation of Pediatric Nonalcoholic Fatty Liver Disease." Investigative Radiology 54.4 (2019): 198-203.
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