Time Harmonic Elastography Reveals Sensitivity of Liver Stiffness to Water Ingestion
Ipek-Ugay S, Tzschaetzsch H, Hudert C, Garcia SRM, Fischer T, Braun J, Althoff C, Sack I (2016)
Publication Type: Journal article
Publication year: 2016
Journal
Book Volume: 42
Pages Range: 1289-1294
Journal Issue: 6
DOI: 10.1016/j.ultrasmedbio.2015.12.026
Abstract
The aim of the study was to test the sensitivity of liver stiffness (LS) measured by time harmonic elastography in large tissue windows to water uptake and post-prandial effects. Each subject gave written informed consent to participate in this institutional review board-approved prospective study. LS was measured by time harmonic elastography in 10 healthy volunteers pre- and post-prandially, as well as before, directly after and 2 h after drinking water. The LS–time function during water intake was measured in 14 scans over 3 h in five volunteers. LS increased by 10% (p = 0.0015) post-prandially and by 11% (p = 0.0024) after pure water ingestion, and decreased to normal values after 2 h. LS was lower after overnight fasting than after 2-h fasting (3%, p = 0.04). Over the time course, LS increased to post-water peak values 15 min after drinking 0.25 L water and remained unaffected by further ingestion of water. In conclusion, our study indicates that LS measured by time harmonic elastography represents an effective-medium property sensitive to physiologic changes in vascular load of the liver.
Involved external institutions
Germany (DE)How to cite
APA:
Ipek-Ugay, S., Tzschaetzsch, H., Hudert, C., Garcia, S.R.M., Fischer, T., Braun, J.,... Sack, I. (2016). Time Harmonic Elastography Reveals Sensitivity of Liver Stiffness to Water Ingestion. Ultrasound in Medicine and Biology, 42(6), 1289-1294. https://doi.org/10.1016/j.ultrasmedbio.2015.12.026
MLA:
Ipek-Ugay, Selcan, et al. "Time Harmonic Elastography Reveals Sensitivity of Liver Stiffness to Water Ingestion." Ultrasound in Medicine and Biology 42.6 (2016): 1289-1294.
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