Magnetorelaxometry for in-vivo quantification of magnetic nanoparticle distributions after magnetic drug targeting in a rabbit carcinoma model

Wiekhorst F, Liebl M, Steinhoff U, Trahms L, Lyer S, Dürr S, Alexiou C (2012)

Publication Type: Conference contribution

Publication year: 2012

Publisher: Springer Science and Business Media, LLC

Book Volume: 140

Pages Range: 301-305

Conference Proceedings Title: Springer Proceedings in Physics

Event location: Lubeck, DEU

ISBN: 9783642241321

DOI: 10.1007/978-3-642-24133-8_48

Abstract

Multi-channel magnetorelaxometry (MRX) is demonstrated to locate and quantify several foci of a magnetic nanoparticle (MNP) distribution after magnetic drug targeting (MDT) in an in-vivo rabbit carcinoma model. By this non-invasively technique MNP accumulations of lateral extensions up to 20 x 30 cm2 can easily be accessed in biological tissue. The total measurement duration of about 20 min including preparation of the rabbit and measurement of two regions of interests (ROI), tumor and thorax (liver, lung and spleen), enables a high throughput of animals. Modelling the MNP distribution either by magnetic point dipoles (ROI tumor) or by an extended, homogenously magnetized body (ROI thorax) of simple geometry, e.g. cuboid, the total magnetic moment and location of each focus is determined by minimum norm estimation. Simultaneously, vital functions like respiration and heart activity can be monitored directly and non-invasively during the MRX measurements. Thus, our MRX procedure gains valuable information for monitoring of MDT procedures in large scale animal models.

Authors with CRIS profile

Stefan Lyer Department of Otorhinolaryngology – Head and Neck Surgery Stephan Dürr Lehrstuhl für Hals-, Nasen- und Ohrenheilkunde Christoph Alexiou Professur für Nanomedizin

Involved external institutions

Physikalisch-Technische Bundesanstalt (PTB) DE Germany (DE)

How to cite

APA:

Wiekhorst, F., Liebl, M., Steinhoff, U., Trahms, L., Lyer, S., Dürr, S., & Alexiou, C. (2012). Magnetorelaxometry for in-vivo quantification of magnetic nanoparticle distributions after magnetic drug targeting in a rabbit carcinoma model. In Jorn Borgert, Thorsten M. Buzug (Eds.), Springer Proceedings in Physics (pp. 301-305). Lubeck, DEU: Springer Science and Business Media, LLC.

MLA:

Wiekhorst, Frank, et al. "Magnetorelaxometry for in-vivo quantification of magnetic nanoparticle distributions after magnetic drug targeting in a rabbit carcinoma model." Proceedings of the 2nd International Workshop on Magnetic Particle Imaging, IWMPI 2012, Lubeck, DEU Ed. Jorn Borgert, Thorsten M. Buzug, Springer Science and Business Media, LLC, 2012. 301-305.

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