Tolvaptan induces body fluid loss and subsequent water conservation in normal rats
Kidoguchi S, Kitada K, Fujisawa Y, Nakano D, Yokoo T, Titze J, Nishiyama A (2022)
Publication Type: Journal article
Publication year: 2022
Journal
Book Volume: 149
Pages Range: 115-123
Journal Issue: 3
DOI: 10.1016/j.jphs.2022.04.008
Abstract
We have recently reported that the urea osmolyte-associated water conservation system is activated in fluid loss models such as high salt-induced natriuresis, renal injury-induced impaired renal concentrating ability, or skin barrier dysfunction-induced transepidermal water loss. The system consists of the interaction of multiple organs including renal urea recycling, hepato-muscular ureagenesis, and suppression of cardiovascular energy expenditure. Here, we determined the effect of pharmacological fluid loss induced by tolvaptan, a selective vasopressin V2 receptor antagonist, on water conservation. We evaluated the water conservation system in rats that consumed a control diet or a diet containing 0.1% tolvaptan. Tolvaptan increased urine volume on day 1, but this renal water loss then gradually decreased. Body water and osmolyte content were decreased by tolvaptan on day 1 but had normalized by day 7. Tolvaptan induced fluid loss on day 1, and the following restoration of body fluid on day 7 was associated with an increase in urea transporter A1-associated renal urea recycling. Tolvaptan did not affect hepato-muscular ureagenesis on day 1 and day 7, or cardiovascular energy expenditure during treatment. Thus, tolvaptan-induced fluid loss leads to activation of the water conservation system via renal urea recycling.
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Japan (JP)How to cite
APA:
Kidoguchi, S., Kitada, K., Fujisawa, Y., Nakano, D., Yokoo, T., Titze, J., & Nishiyama, A. (2022). Tolvaptan induces body fluid loss and subsequent water conservation in normal rats. Journal of Pharmacological Sciences, 149(3), 115-123. https://doi.org/10.1016/j.jphs.2022.04.008
MLA:
Kidoguchi, Satoshi, et al. "Tolvaptan induces body fluid loss and subsequent water conservation in normal rats." Journal of Pharmacological Sciences 149.3 (2022): 115-123.
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