Prospective Studies on the Risk of Rheumatoid Arthritis: The European Risk RA Registry

Studenic P, Hensvold A, Kleyer A, Van Der Helm-Van Mil A, Pratt AG, Sieghart D, Krönke G, Williams R, De Souza S, Karlfeldt S, Johannesson M, Krogh NS, Klareskog L, Catrina AI (2022)

Publication Type: Journal article

Publication year: 2022

Journal

Frontiers in Medicine Frontiers Media

Book Volume: 9

Article Number: 824501

DOI: 10.3389/fmed.2022.824501

Abstract

Background: The accumulation of risk for the development of rheumatoid arthritis (RA) is regarded as a continuum that may start with interacting environmental and genetic factors, proceed with the initiation of autoimmunity, and result in the formation of autoantibodies such as anti-citrullinated peptide antibodies (ACPA). In parallel, at-risk individuals may be asymptomatic or experience joint pain (arthralgia) that is itself non-specific or clinically suspicious for evolving RA, even in the absence of overt arthritis. Optimal strategies for the management of people at-risk of RA, both for symptom control and to delay or prevent progression to classifiable disease, remain poorly understood. Methods: To help address this, groups of stakeholders from academia, clinical rheumatology, industry and patient research partners have collaborated to advance understanding, define and study different phases of the at-risk state. In this current report we describe different European initiatives in the field and the successful effort to build a European Registry of at-risk people to facilitate observational and interventional research. Results: We outline similarities and differences between cohorts of at-risk individuals at institutions spanning several countries, and how to best combine them within the new database. Over the past 2 years, besides building the technical infrastructure, we have agreed on a core set of variables that all partners should strive to collect for harmonization purposes. Conclusion: We emphasize to address this process from different angles and touch on the biologic, epidemiologic, analytic, and regulatory aspects of collaborative studies within a meta-database of people at-risk of RA.

Authors with CRIS profile

Arnd Kleyer Department of Medicine 3 – Rheumatology and Immunology Gerhard Krönke Professur für Translationale Immunologie

Involved external institutions

Newcastle University GB United Kingdom (GB) Karolinska Institute SE Sweden (SE) King’s College London GB United Kingdom (GB) Medizinische Universität Wien AT Austria (AT) Leiden University NL Netherlands (NL)

How to cite

APA:

Studenic, P., Hensvold, A., Kleyer, A., Van Der Helm-Van Mil, A., Pratt, A.G., Sieghart, D.,... Catrina, A.I. (2022). Prospective Studies on the Risk of Rheumatoid Arthritis: The European Risk RA Registry. Frontiers in Medicine, 9. https://doi.org/10.3389/fmed.2022.824501

MLA:

Studenic, Paul, et al. "Prospective Studies on the Risk of Rheumatoid Arthritis: The European Risk RA Registry." Frontiers in Medicine 9 (2022).

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