Sildenafil Affects Olfactory Function
Gudziol V, Mück-Weymann M, Seizinger O, Rauh R, Hummel T (2007)
Publication Type: Journal article, Original article
Publication year: 2007
Journal
Book Volume: 177
Pages Range: 258-261
Journal Issue: 1
DOI: 10.1016/j.juro.2006.08.060
Abstract
Purpose: Sildenafil is the first member of a new class of oral drugs effective for erectile dysfunction. However, approximately 20% of patients complain about nasal congestion after sildenafil administration. Materials and Methods: Because nasal airflow and olfaction are closely linked, the sense of smell was evaluated in 20 young, healthy volunteers after the administration of 50 and 100 mg sildenafil, and placebo in a double-blinded, crossover study. Olfactory function was evaluated using a standardized and validated test (Sniffin' Sticks®). To investigate a possible impact of G-protein β3 subunit C825T polymorphism on the effect of sildenafil on olfaction the genotype of all subjects was determined. Results: The effect of sildenafil on olfaction was only present at a dose of 100 mg but not at a dose of 50 mg sildenafil. The genotypes TT, CC and TC of the G-protein β3 C825T polymorphism had no impact on the change in olfactory function. Conclusions: Higher sildenafil doses may produce decreased olfactory sensitivity. © 2007 American Urological Association.
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Germany (DE)How to cite
APA:
Gudziol, V., Mück-Weymann, M., Seizinger, O., Rauh, R., & Hummel, T. (2007). Sildenafil Affects Olfactory Function. Journal of Urology, 177(1), 258-261. https://doi.org/10.1016/j.juro.2006.08.060
MLA:
Gudziol, V., et al. "Sildenafil Affects Olfactory Function." Journal of Urology 177.1 (2007): 258-261.
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