A network analysis of drug combinations associated with acute generalized exanthematous pustulosis (AGEP)
la Torre AMD, van Weenen E, Kraus M, Weiler S, Feuerriegel S, Burden AM (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 10
Article Number: 4486
Journal Issue: 19
DOI: 10.3390/jcm10194486
Abstract
Acute generalized exanthematous pustulosis (AGEP) is a rare skin adverse drug reaction. The pathophysiology and causative drugs associated with AGEP are poorly understood, with the majority of studies in AGEP focusing on a single-drug-outcome association. We therefore aimed to explore and characterize frequently reported drug combinations associated with AGEP using the WHO pharmacovigilance database VigiBase. In this explorative cross-sectional study of a pharmacovigilance database using a data-driven approach, we assessed individual case safety reports (ICSR) with two or more drugs reported to VigiBase. A total of 2649 ICSRs reported two or more drugs. Cardiovascular drugs, including antithrombotics and beta-blockers, were frequently reported in combination with other drugs, particularly antibiotics. The drug pair of amoxicillin and furosemide was reported in 57 ICSRs (2.2%), with an O/E ratio of 1.3, and the combination of bisoprolol and furosemide was recorded 44 times (1.7%), with an O/E ratio of 5.5. The network analysis identified 10 different communities of varying sizes. The largest cluster primarily consisted of cardiovascular drugs. This data-driven and exploratory study provides the largest real-world assessment of drugs associated with AGEP to date. The results identify a high frequency of cardiovascular drugs, particularly used in combination with antibiotics.
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APA:
la Torre, A.M.D., van Weenen, E., Kraus, M., Weiler, S., Feuerriegel, S., & Burden, A.M. (2021). A network analysis of drug combinations associated with acute generalized exanthematous pustulosis (AGEP). Journal of Clinical Medicine, 10(19). https://doi.org/10.3390/jcm10194486
MLA:
la Torre, Adrian Martinez De, et al. "A network analysis of drug combinations associated with acute generalized exanthematous pustulosis (AGEP)." Journal of Clinical Medicine 10.19 (2021).
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