Shinde SS, Bolik KV, Maschauer S, Prante O (2021)
Publication Type: Journal article
Publication year: 2021
Book Volume: 14
Article Number: 833
Journal Issue: 9
DOI: 10.3390/ph14090833
The18F syntheses of tracers for positron emission tomography (PET) typically require several steps, including extraction of [18F]fluoride from H2[18O]O, elution, and drying, prior to nucleo-philic substitution reaction, being a laborious and time-consuming process. The elution of [18F]fluo-ride is commonly achieved by phase transfer catalysts (PTC) in aqueous solution, which makes aze-otropic drying indispensable. The ideal PTC is characterized by a slightly basic nature, its capacity to elute [18F]fluoride with anhydrous solvents, and its efficient complex formation with [18F]fluoride during subsequent labeling. Herein, we developed tri-(tert-butanol)-methylammonium iodide (TBMA-I), a quaternary ammonium salt serving as the PTC for18F-fluorination reactions. The favorable elution efficiency of [18F]fluoride using TBMA-I was demonstrated with aprotic and protic sol-vents, maintaining high18F-recoveries of 96–99%.18F-labeling reactions using TBMA-I as PTC were studied with aliphatic 1,3-ditosylpropane and aryl pinacol boronate esters as precursors, providing 18 F-labeled products in moderate-to-high radiochemical yields. TBMA-I revealed adequate properties for application to18F-fluorination reactions and could be used for elution of [18F]fluoride with MeOH, omitting an additional base and azeotropic drying prior to18F-labeling. We speculate that the tert-alcohol functionality of TBMA-I promotes intermolecular hydrogen bonding, which en-hances the elution efficiency and stability of [18F]fluoride during nucleophilic18F-fluorination.
APA:
Shinde, S.S., Bolik, K.-V., Maschauer, S., & Prante, O. (2021). 18 f-fluorination using tri-tert-butanol ammonium iodide as phase-transfer catalyst: An alternative minimalist approach. Pharmaceuticals, 14(9). https://doi.org/10.3390/ph14090833
MLA:
Shinde, Sandip S., et al. "18 f-fluorination using tri-tert-butanol ammonium iodide as phase-transfer catalyst: An alternative minimalist approach." Pharmaceuticals 14.9 (2021).
BibTeX: Download