Ligand‐tuning of the stability of pd(Ii) conjugates with cyanocobalamin
Porębska D, Orzeł Ł, Rutkowska‐zbik D, Stochel G, van Eldik R (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 22
Article Number: 7973
Journal Issue: 15
DOI: 10.3390/ijms22157973
Abstract
Besides the well‐known functions performed by vitamin B12 (CblCN) in biochemical processes of the human body, an increasing interest has been raised by the possibility of its use as a transmembrane drug carrier, capable, among others, of enhancing the accumulation of inorganic cytostatics in cancer cells. The present study was aimed at determining the possibility of the formation of CblCN conjugates with Pd(II) complexes. A key aspect was their stability, which we attempted to tune by appropriate choice of ligands. Syntheses, spectroscopic analysis of postreaction systems and kinetic investigations of conjugate formation reactions, have been complemented by DFT modelling. The obtained results showed that ligand charge, geometry and electron affinity may have a significant impact on carrier binding and release leading to the activation of the Pd(II) complex. This provides a rationale to expect that with appropriate composition of the coordination sphere, it will be possible to extend the spectrum of less toxic inorganic chemotherapeutics.
Authors with CRIS profile
Involved external institutions
Jagiellonian University / Uniwersytet Jagielloński (UJ)
Poland (PL)
Jerzy Haber Institute of Catalysis and Surface Chemistry (ICSC, ICSC PAS) / Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera
Poland (PL)
Poland (PL)
Jerzy Haber Institute of Catalysis and Surface Chemistry (ICSC, ICSC PAS) / Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera
Poland (PL)
How to cite
APA:
Porębska, D., Orzeł, Ł., Rutkowska‐zbik, D., Stochel, G., & van Eldik, R. (2021). Ligand‐tuning of the stability of pd(Ii) conjugates with cyanocobalamin. International Journal of Molecular Sciences, 22(15). https://doi.org/10.3390/ijms22157973
MLA:
Porębska, Dominika, et al. "Ligand‐tuning of the stability of pd(Ii) conjugates with cyanocobalamin." International Journal of Molecular Sciences 22.15 (2021).
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