Biogenic and Biomimetic Carriers as Versatile Transporters to Treat Infections
Goes A, Fuhrmann G (2018)
Publication Type: Journal article, Review article
Publication year: 2018
Journal
Book Volume: 4
Pages Range: 881-892
Journal Issue: 6
DOI: 10.1021/acsinfecdis.8b00030
Abstract
Biogenic and biomimetic therapeutics are a relatively new class of systems that are of physiological origin and/or take advantage of natural pathways or aim at mimicking these to improve selective interaction with target tissue. The number of biogenic and bioengineered avenues for drug therapy and diagnostics has multiplied over the past years for many applications, indicating the high expectations associated with this biological route. Nevertheless, the use of "bio"-related approaches for treating or diagnosing infectious diseases is still rare. Given that infectious diseases, in particular bacterial resistances, are seriously on the rise, there is an urgent need to take advantage of biogenic and bioengineered systems to target these challenges. In this manuscript, we first give a definition of the various "bio" terms, including biogenic, biomimetic, bioinspired, and bioengineered and we highlight them using tangible applications in the field of infectious diseases. Our examples cover cell-derived systems, including bioengineered bacteria, virus-like particles, and different cell-mimetics. Moreover, we discuss natural and bioengineered particles such as extracellular vesicles from mammalian and bacterial sources and liposomes. A concluding section outlines the potential for biomaterial-related avenues to overcome challenges associated with difficult-to-treat infections. We critically discuss benefits and risks for these applications and give an outlook on the future of biogenic engineering.
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Germany (DE)How to cite
APA:
Goes, A., & Fuhrmann, G. (2018). Biogenic and Biomimetic Carriers as Versatile Transporters to Treat Infections. ACS Infectious Diseases, 4(6), 881-892. https://doi.org/10.1021/acsinfecdis.8b00030
MLA:
Goes, Adriely, and Gregor Fuhrmann. "Biogenic and Biomimetic Carriers as Versatile Transporters to Treat Infections." ACS Infectious Diseases 4.6 (2018): 881-892.
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