Role of Microparticles in Cardiovascular Disease Implications for Endothelial Dysfunction, Thrombosis, and Inflammation
Lugo-Gavidia LM, Burger D, Matthews VB, Nolde JM, Galindo Kiuchi M, Carnagarin R, Kannenkeril D, Chan J, Joyson A, Herat LY, Azzam O, Schlaich MP (2021)
Publication Type: Journal article, Review article
Publication year: 2021
Journal
Book Volume: 77
Pages Range: 1825-1844
Journal Issue: 6
DOI: 10.1161/HYPERTENSIONAHA.121.16975
Abstract
Microparticles are small cell vesicles that are derived from the cell membrane in response to different biological processes. There is growing evidence supporting the association between microparticles and cardiovascular disease, as their pathophysiology commonly includes endothelial damage and chronic inflammation which also promote a prothrombotic state. The direct causal link between the release of the different subtypes of microparticles and their implications on physiological and pathological conditions is still not completely elucidated. However, evidence suggests microparticles released from platelets, leukocytes, and endothelium may help to evaluate vascular health as they have a relevant role in inflammation, endothelial function, and thrombosis. This review aims to provide a short overview of the biogenesis, characteristics, and detection methodology of microparticles with a special focus on their possible implication in cardiovascular settings.
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Australia (AU)
Canada (CA)How to cite
APA:
Lugo-Gavidia, L.M., Burger, D., Matthews, V.B., Nolde, J.M., Galindo Kiuchi, M., Carnagarin, R.,... Schlaich, M.P. (2021). Role of Microparticles in Cardiovascular Disease Implications for Endothelial Dysfunction, Thrombosis, and Inflammation. Hypertension, 77(6), 1825-1844. https://doi.org/10.1161/HYPERTENSIONAHA.121.16975
MLA:
Lugo-Gavidia, Leslie Marisol, et al. "Role of Microparticles in Cardiovascular Disease Implications for Endothelial Dysfunction, Thrombosis, and Inflammation." Hypertension 77.6 (2021): 1825-1844.
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