CaCO3 crystals as versatile carriers for controlled delivery of antimicrobials
Ferreira AM, Vikulina AS, Volodkin D (2020)
Publication Type: Journal article, Review article
Publication year: 2020
Journal
Book Volume: 328
Pages Range: 470-489
DOI: 10.1016/j.jconrel.2020.08.061
Abstract
CaCO3 crystals have been known for a long time as naturally derived and simply fabricated nano(micro)-sized materials able to effectively host and release various molecules. This review summarises the use of CaCO3 crystals as versatile carriers to host, protect and release antimicrobials, offering a strong tool to tackle antimicrobial resistance, a serious global health problem. The main methods for the synthesis of CaCO3 crystals with different properties, as well as the approaches for the loading and release of antimicrobials are presented. Finally, prospects to utilize the crystals in order to improve the therapeutic outcome and combat antimicrobial resistance are highlighted. Ultimately, this review intends to provide an in-depth overview of the application of CaCO3 crystals for the smart and controlled delivery of antimicrobial agents and aims at identifying the advantages and drawbacks as well as guiding future works, research directions and industrial applications.
Authors with CRIS profile
Involved external institutions
Nottingham Trent University
United Kingdom (GB)
Fraunhofer-Institut für Zelltherapie und Immunologie (IZI)
Germany (DE)
United Kingdom (GB)
Fraunhofer-Institut für Zelltherapie und Immunologie (IZI)
Germany (DE)
How to cite
APA:
Ferreira, A.M., Vikulina, A.S., & Volodkin, D. (2020). CaCO3 crystals as versatile carriers for controlled delivery of antimicrobials. Journal of Controlled Release, 328, 470-489. https://doi.org/10.1016/j.jconrel.2020.08.061
MLA:
Ferreira, Ana M., Anna S. Vikulina, and Dmitry Volodkin. "CaCO3 crystals as versatile carriers for controlled delivery of antimicrobials." Journal of Controlled Release 328 (2020): 470-489.
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