Update Breast Cancer 2021 Part 2-Advanced Stages, Long-Term Consequences and Biomarkers

Ditsch N, Stickeler E, Behrens A, Belleville E, Fasching P, Fehm TN, Hartkopf AD, Jackisch C, Janni W, Kolberg-Liedtke C, Kolberg HC, Lueftner D, Lux MP, Mueller V, Schneeweiss A, Schuetz F, Schulmeyer CE, Tesch H, Thomssen C, Uleer C, Untch M, Welslau M, Woeckel A, Wurmthaler L, Wuerstlein R, Thill M, Aktas B (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

DOI: 10.1055/a-1464-1221

Abstract

This review summarises and discusses significant aspects of recently published studies on patient treatment in advanced breast cancer and on biomarkers in breast cancer. In recent years, a large number of drugs for all molecular subtypes have been developed up to phase III trials. With regard to immune checkpoint inhibitors in metastasised breast cancer, the recent discussion has centred on the best candidate for combined chemotherapy. The oral taxanes could become a new type of oral chemotherapies. There is a growing body of data on biomarkers for the use of CDK4/6 inhibitors, which could also signify further development for other molecular subtypes. New substances have been developed for metastatic HER2+ breast cancer that still result in good remission even after massive prior treatment and/or cerebral metastasis. Similarly, knowledge is growing about targeted therapies with antibody-drug conjugates (ADC) against Trop-2, which could bolster our therapeutic armoury in triple-negative breast cancer (TNBC). In addition, the clinical focus is on understanding how to maintain fertility after breast cancer treatment. Here, pooled analyses provide new insights.

Authors with CRIS profile

Involved external institutions

Universitätsklinikum Düsseldorf Germany (DE) Centrum für Hämatologie und Onkologie Bethanien Germany (DE) Agaplesion Markus Krankenhaus Germany (DE) HELIOS Kliniken Germany (DE) Universitätsklinikum Leipzig Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Diakonissen-Stiftungs-Krankenhaus Speyer Germany (DE) ClinSol GmbH & Co.KG Germany (DE) Universitätsklinikum Aachen (UKA) Germany (DE) Universitätsklinikum Würzburg Germany (DE) Universitätsklinikum Heidelberg Germany (DE) Ludwig-Maximilians-Universität (LMU) Germany (DE) Universitätsklinikum Augsburg Germany (DE) Martin-Luther-Universität Halle-Wittenberg (MLU) Germany (DE) Universitätsklinikum Ulm Germany (DE) Sana Klinikum Offenbach Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Universitätsklinikum Essen Germany (DE) Eberhard Karls Universität Tübingen Germany (DE) Marienhospital Bottrop Germany (DE) St. Vincenz-Krankenhaus Germany (DE)

How to cite

APA:

Ditsch, N., Stickeler, E., Behrens, A., Belleville, E., Fasching, P., Fehm, T.N.,... Aktas, B. (2021). Update Breast Cancer 2021 Part 2-Advanced Stages, Long-Term Consequences and Biomarkers. Geburtshilfe und Frauenheilkunde. https://doi.org/10.1055/a-1464-1221

MLA:

Ditsch, Nina, et al. "Update Breast Cancer 2021 Part 2-Advanced Stages, Long-Term Consequences and Biomarkers." Geburtshilfe und Frauenheilkunde (2021).

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