Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature

Seidel A, Seidel CL, Weider M, Junker R, Gölz L, Schmetzer H (2020)

Publication Type: Journal article, Review article

Publication year: 2020

Journal

International Journal of Molecular Sciences MDPI

Book Volume: 21

Journal Issue: 24

DOI: 10.3390/ijms21249766

Abstract

Natural killer (NK) cells, as members of the innate immune system, and natural killer T (NKT) cells, bridging innate and adaptive immunity, play a prominent role in chronic inflammatory diseases and cancerogenesis, yet have scarcely been examined in oral diseases. Therefore, systematic research on the latest literature focusing on NK/NKT cell-mediated mechanisms in periodontal disease, including the time period 1988-2020, was carried out in MEDLINE (PubMed) using a predetermined search strategy, with a final selection of 25 studies. The results showed that NK cells tend to have rather proinflammatory influences via cytokine production, cytotoxic effects, dendritic-cell-crosstalk, and autoimmune reactions, while contrarily, NKT cell-mediated mechanisms were proinflammatory and immunoregulatory, ranging from protective effects via B-cell-regulation, specific antibody production, and the suppression of autoimmunity to destructive effects via cytokine production, dendritic-cell-crosstalk, and T-/B-cell interactions. Since NK cells seem to have a proinflammatory role in periodontitis, further research should focus on the proinflammatory and immunoregulatory properties of NKT cells in order to create, in addition to antibacterial strategies in dental inflammatory disease, novel anti-inflammatory therapeutic approaches modulating host immunity towards dental health.

Authors with CRIS profile

Matthias Weider Department of Orthodontics and Orofacial Orthopaedics Lina Gölz Lehrstuhl für Zahn-, Mund- und Kieferheilkunde, insbesondere Kieferorthopädie

Involved external institutions

Danube Private University (DPU) AT Austria (AT) Universitätsklinikum der Ludwig-Maximilians-Universität München DE Germany (DE)

How to cite

APA:

Seidel, A., Seidel, C.L., Weider, M., Junker, R., Gölz, L., & Schmetzer, H. (2020). Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature. International Journal of Molecular Sciences, 21(24). https://doi.org/10.3390/ijms21249766

MLA:

Seidel, Andreas, et al. "Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature." International Journal of Molecular Sciences 21.24 (2020).

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