Study protocol for an International Prospective Observational Cohort Study for Optimal Bowel Resection Extent and Central Radicality for Colon Cancer (T-REX study)
Shiozawa M, Ueno H, Shiomi A, Kim NK, Kim JC, Tsarkov P, Grützmann R, Dulskas A, Liang JT, Samalavičius N, West N, Sugihara K (2021)
Publication Type: Journal article
Publication year: 2021
Journal
Book Volume: 51
Pages Range: 145-155
Journal Issue: 1
DOI: 10.1093/jjco/hyaa115
Abstract
This is a prospective observational cohort study aiming to include 4000 patients with stages I to III colon cancer treated at 35 specialist institutions in Japan, South Korea, Germany, Russia, Lithuania and Taiwan. The anatomical distribution of lymph nodes and feeding arteries are investigated using surgical specimens according to pre-specified categorizing methods using intraoperative anatomical markings. Primary analyses are performed to identify the general principles of metastatic lymph node distribution in terms of its relation to the location of the primary tumor and feeding arteries. Secondary analyses will be used to estimate prognostic outcomes according to bowel resection length and central radicality and will be used to evaluate the quality of resected surgical specimens. Through in-depth lymph node mapping, standardized criteria for the definite area of 'regional' lymph node resection in routine surgical procedures can be identified, which is expected to contribute to international standardization in colon cancer surgery (ClinicalTrials.gov NCT02938481).
Authors with CRIS profile
Involved external institutions
University of Ulsan / 울산대학교
Korea, Republic of (KR)
Yonsei University Health System (YUHS)
Korea, Republic of (KR)
University of Leeds
United Kingdom (GB)
Tokyo Medical and Dental University (TMDU) / 東京医科歯科大学
Japan (JP)
National Defense Medical College / 防衛医科大学校
Japan (JP)
Klaipėdos Universitetas
Lithuania (LT)
National Taiwan University Hospital (NTUH) / 國立台灣大學醫學院附設醫院
Taiwan (TW)
Kanagawa Prefectural Hospital / Kanagawa Cancer Center / 神奈川県立がんセンター
Japan (JP)
I.M. Sechenov First Moscow State Medical University
Russian Federation (RU)
Shizuoka Cancer Center (SCC) / 静岡県立 静岡がんセンター
Japan (JP)
Korea, Republic of (KR)
Yonsei University Health System (YUHS)
Korea, Republic of (KR)
University of Leeds
United Kingdom (GB)
Tokyo Medical and Dental University (TMDU) / 東京医科歯科大学
Japan (JP)
National Defense Medical College / 防衛医科大学校
Japan (JP)
Klaipėdos Universitetas
Lithuania (LT)
National Taiwan University Hospital (NTUH) / 國立台灣大學醫學院附設醫院
Taiwan (TW)
Kanagawa Prefectural Hospital / Kanagawa Cancer Center / 神奈川県立がんセンター
Japan (JP)
I.M. Sechenov First Moscow State Medical University
Russian Federation (RU)
Shizuoka Cancer Center (SCC) / 静岡県立 静岡がんセンター
Japan (JP)
How to cite
APA:
Shiozawa, M., Ueno, H., Shiomi, A., Kim, N.K., Kim, J.C., Tsarkov, P.,... Sugihara, K. (2021). Study protocol for an International Prospective Observational Cohort Study for Optimal Bowel Resection Extent and Central Radicality for Colon Cancer (T-REX study). Japanese Journal of Clinical Oncology, 51(1), 145-155. https://doi.org/10.1093/jjco/hyaa115
MLA:
Shiozawa, Manabu, et al. "Study protocol for an International Prospective Observational Cohort Study for Optimal Bowel Resection Extent and Central Radicality for Colon Cancer (T-REX study)." Japanese Journal of Clinical Oncology 51.1 (2021): 145-155.
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