Role of protein kinase C in podocytes and development of glomerular damage in diabetic nephropathy

Teng B, Duong M, Tossidou I, Yu X, Schiffer M (2014)

Publication Type: Journal article, Review article

Publication year: 2014

Journal

Frontiers in Endocrinology Frontiers Media

Book Volume: 5

Article Number: 179

Journal Issue: NOV

DOI: 10.3389/fendo.2014.00179

Abstract

The early glomerular changes in diabetes include a podocyte phenotype with loss of slit diaphragm proteins, changes in the actin cytoskeleton and foot process architecture. This review focuses on the role of the protein kinase C (PKC) family in podocytes and points out the differential roles of classical, novel, and atypical PKCs in podocytes. Some PKC isoforms are indispensable for proper glomerular development and slit diaphragm maintenance, whereas others might be harmful when activated in the diabetic milieu. Therefore, some might be interesting treatment targets in the early phase of diabetes.

Authors with CRIS profile

Mario Schiffer

Involved external institutions

Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE)

How to cite

APA:

Teng, B., Duong, M., Tossidou, I., Yu, X., & Schiffer, M. (2014). Role of protein kinase C in podocytes and development of glomerular damage in diabetic nephropathy. Frontiers in Endocrinology, 5(NOV). https://doi.org/10.3389/fendo.2014.00179

MLA:

Teng, Beina, et al. "Role of protein kinase C in podocytes and development of glomerular damage in diabetic nephropathy." Frontiers in Endocrinology 5.NOV (2014).

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