Paramagnetic chemical exchange saturation transfer agents and their perspectives for application in magnetic resonance imaging

Rodríguez-Rodríguez A, Zaiß M, Esteban-Gómez D, Angelovski G, Platas-Iglesias C (2021)

Publication Type: Journal article, Review article

Publication year: 2021

Journal

International Reviews in Physical Chemistry Taylor & Francis: STM, Behavioural Science and Public Health Titles

Book Volume: 40

Pages Range: 51-79

Journal Issue: 1

DOI: 10.1080/0144235X.2020.1823167

Abstract

Magnetic resonance imaging (MRI) has emerged as very important tool in biomedical research and is an essential diagnostic method in clinical radiology today. Lately, chemical exchange saturation transfer (CEST) has become a very attractive alternative to the classical MRI methodologies. CEST uses a unique operating mechanism to generate contrast and possesses great potential for functional imaging investigations, especially in combination with diamagnetic and paramagnetic (dia- and paraCEST, respectively) contrast agents. However, CEST is governed by a combination of several parameters that together influence the overall intensity of observed CEST effect. The understanding of the physics of CEST has advanced significantly to provide a reliable assessment on contribution of individual parameters important for generation of a CEST signal. Nevertheless, there seem to be a missing link between the above mentioned theory and its practical application, especially in the development of new probes. This review article provides background information on CEST and paraCEST, analyzing the importance of the main physical parameters, such as exchange rate, saturation power and time, or paramagnetic shift and relaxation times. We describe the different types of paramagnetic complexes based on lanthanide or transition metal ions, and discuss their properties in the context of potential CEST application.

Authors with CRIS profile

Moritz Zaiß Professur für Multimodale Bildgebung in der klinischen Forschung

Involved external institutions

University of A Coruña / Universidade da Coruña ES Spain (ES) Max-Planck-Institut für biologische Kybernetik / Max Planck Institute for Biological Cybernetics DE Germany (DE)

How to cite

APA:

Rodríguez-Rodríguez, A., Zaiß, M., Esteban-Gómez, D., Angelovski, G., & Platas-Iglesias, C. (2021). Paramagnetic chemical exchange saturation transfer agents and their perspectives for application in magnetic resonance imaging. International Reviews in Physical Chemistry, 40(1), 51-79. https://doi.org/10.1080/0144235X.2020.1823167

MLA:

Rodríguez-Rodríguez, Aurora, et al. "Paramagnetic chemical exchange saturation transfer agents and their perspectives for application in magnetic resonance imaging." International Reviews in Physical Chemistry 40.1 (2021): 51-79.

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